Expression and clinical significance of B7-H5 in patients with chronic hepatitis B and HBV-related hepatocellular carcinoma
10.3969/j.issn.1673-4130.2025.11.009
- VernacularTitle:B7-H5在慢性乙型肝炎及HBV相关肝癌患者中的表达及临床意义
- Author:
Chen ZHAO
1
;
Ruhong YAN
;
Changsong ZHANG
;
Jiangtao WEN
;
Ting WANG
Author Information
1. 南京大学医学院附属苏州医院检验科,江苏苏州 215153
- Keywords:
B7-H5;
chronic hepatitis B;
hepatitis B virus-related hepatocellular carcinoma
- From:
International Journal of Laboratory Medicine
2025;46(11):1325-1328,1335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of B7-H5 in patients with chro-nic hepatitis B and hepatitis B virus(HBV)-related hepatocellular carcinoma.Methods Enzyme-linked immu-nosorbent assay(ELISA)was used to detect the serum levels of B7-H5 in 104 patients with chronic hepatitis B,28 patients with HBV-related hepatocellular carcinoma and 35 healthy controls.And statistical methods were used to analyze the difference,correlation and diagnostic value of the results.Results The serum levels of B7-H5 in patients with HBV-related hepatocellular carcinoma,patients with chronic hepatitis B and healthy subjects were statistically different(P＜0.05),and the level from high to low was HBV-related liver cancer patients,chronic hepatitis B patients,healthy subjects.The serum level of B7-H5 in chronic hepatitis B pa-tients with negative HBV-DNA was significantly higher than that in healthy subjects(P＜0.01).The level of B7-H5 in patients with chronic hepatitis B was positively correlated with HBV-DNA load(P＜0.05).And the level of B7-H5 in patients with HBV-related hepatocellular carcinoma was positively correlated with HBsAg,HBeAg and AFP levels(P＜0.05).In addition,B7-H5 had diagnostic value for chronic hepatitis B and HBV-related hepatocellular carcinoma(P＜0.01),and the diagnostic value for HBV-related hepatocellular carcino-ma was higher than that for chronic hepatitis B.The level of B7-H5 in patients with HBV-related hepatocellu-lar carcinoma after surgery was significantly lower than that before surgery(P＜0.05).Conclusion Serum levels of B7-H5 is related to the progression of CHB and HBV-related hepatocellular carcinoma,and can be considered as an effective detection index for the auxiliary diagnosis and the judgment of postoperative condi-tion of CHB and HBV-related hepatocellular carcinoma.
