Correlation between serum Gal-3,FGF-21 and lung function and mMRC score in patients with COPD
10.3969/j.issn.1673-4130.2025.10.012
- VernacularTitle:血清Gal-3、FGF-21与COPD患者肺功能及mMRC评分的相关性研究
- Author:
Weiwei CHEN
1
;
Mengmeng GAO
;
Yue LIU
;
Jing XU
;
Fengyuan ZHU
;
Fei LI
;
Meiru FAN
;
Yongqing HE
Author Information
1. 沧州市人民医院呼吸与危重症医学科二区(老年医学科),河北沧州 061000
- Keywords:
serum galectin-3;
fibroblast growth factor-21;
chronic obstructive pulmonary disease;
lung function;
dyspnea index
- From:
International Journal of Laboratory Medicine
2025;46(10):1212-1215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum galectin-3(Gal-3),fibroblast growth factor-21(FGF-21)and the lung function and and the Modified British Medical Research Council dyspnea in-dex(mMRC)score in invalids with chronic obstructive pulmonary disease(COPD).Methods A total of 79 patients with COPD who received treatment in the hospital from April 2021 to April 2023 were selected as the observation group,and 60 healthy individuals in the hospital during the same period were selected as control group.The expressions of Gal-3 and FGF-21 in serum were detected and compared.The first second forced ex-piratory volume(FEV1),FEV1/forced vital capacity(FVC)and mMRC score in two groups were compared,and the correlation between the expression levels of Gal-3 and FGF-21 and FEV1,FEV1/FVC and mMRC score in COPD patients was analyzed.Results The expression levels of serum Gal-3 and FGF-21 in the obser-vation group were higher than those in the control group(P＜0.05).The pulmonary function indexes in ser-um of observation group were higher than those in the control group,while the mMRC score was lower than that in the control group(P＜0.05).The expression levels of Gal-3 and FGF-21 were positively correlated with FEV1 and FEV1/FVC(P＜0.05),was negatively correlated with mMRC score(P＜0.05).Conclusion The expression of serum Gal-3 and FGF-21 in COPD invalids is abnormal,and the expression levels of serum Gal-3 and FGF-21 in COPD patients were correlated with FEV1,FEV1/FVC and mMRC score,which could be used as important reference indicators for diagnosis and disease evaluation of COPD.
