Risk factor and prognosis of critically ill patients infected with Acinetobacter baumanni
10.3969/j.issn.1673-4130.2025.10.005
- VernacularTitle:重症患者合并感染鲍曼不动杆菌的危险因素及预后分析
- Author:
Naobei YE
1
;
Pan ZHANG
;
Jian REN
;
Hongxia WANG
;
Xingyu QIN
;
Haonan SUN
;
Shuhan XU
;
Ruiqin ZHANG
Author Information
1. 山西医科大学药学院,山西太原 030000
- Keywords:
Acinetobacter baumannii;
nosocomial infection;
intensive care unit;
carbapenem resist-ance;
risk factors
- From:
International Journal of Laboratory Medicine
2025;46(10):1173-1179,1184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of critically ill patients infected with Acinetobacter bau-mannii(AB)and carbapenem resistant Acinetobacter baumannii(CRAB).Methods From January 2022 to June 2023,the data of Intensive Care Unit(ICU)patients admitted to Second Hospital of Shanxi Medical Uni-versity in Shanxi Province were collected.According to whether they were infected with AB,the patients were divided into an observation group and a control group(98 cases each).The observation group was further di-vided into a carbapenem sensitive Acinetobacter baumannii(CSAB)group(72 cases)and a CRAB group(26 cases).Mann-Whitney U test,chi-square test and other univariate and multivariate binary Logistic regression were used to analyze the risk factors of AB and CRAB infection for critically ill patients.The prognosis was analyzed by Kaplan Meier survival analysis.Results Long stay in ICU,previous use of carbapenem drugs and high Acute Physiology and Health Evaluation(APACHE Ⅱ)score were independent risk factors for AB sus-ceptibility(P＜0.05),while the independent risk factors for CRAB susceptibility were invasive ventilation and delayed surgery(P＜0.01).In addition,CRAB infection,COVID-19 and shock was risk factors for death in critically ill patients,and invasive ventilation,indwelling drainage tube and operation could reduce the risk of death in critically ill patients(P＜0.05).Conclusion ICU stay time,APACHE Ⅱ score,previous use of car-bapenem drugs and invasive ventilation increase the risk of AB and CRAB infection in critically ill patients.In-vasive ventilation,indwelling drainage and early surgery could reduce the risk of death from AB and CRAB in-fection in critically ill patients.
