Potential association of serum MAO and sST2 levels with coronary slow flow and its clinical value
10.3969/j.issn.1673-4130.2025.10.004
- VernacularTitle:血清MAO、sST2水平与冠状动脉慢血流的潜在关联及其临床价值
- Author:
Xiangquan TIAN
1
;
Peng CHEN
;
Li LUO
;
Zhongcai FAN
Author Information
1. 川北医学院附属大竹医院心内科,四川达州 635100
- Keywords:
monoamine oxidase;
soluble suppression of tumorigenicity 2 protein;
coronary slow flow;
TIMI frame count
- From:
International Journal of Laboratory Medicine
2025;46(10):1167-1172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum monoamine oxidase(MAO),soluble growth stimulation expressed gene 2(sST2)and coronary slow flow(CSF),and to evaluate their value in pre-dicting CSF risk and guiding clinical decision-making.Methods A total of 118 patients with CSF confirmed by coronary angiography from January 2022 to September Dazhu Hospital Affiliated to North Sichuan Medical College 2023 were selected as the observation group,while 120 patients with normal coronary blood flow were selected as the control group.The coronary flow velocity was assessed using the TIMI frame count(TFC).Baseline characteristics,as well as serum MAO and sST2 levels,were compared between the two groups.Multi model calibration Logistic regression analysis was used to examine the relationship between the two markers and CSF.Pearson correlation analysis was conducted to evaluate the association between the markers and TFC.The predictive efficacy of MAO and sST2 for CSF and their benefit in clinical decision-making were as-sessed using receiver operating characteristic(ROC)curve and decision curve analysis(DCA).Results(1)The levels of body mass index(BMI),smoking proportion,C-reactive protein(CRP),uric acid(UA),creati-nine(Cr),MAO,and sST2 in the observation group were all higher than those in the control group(P＜0.05).(2)The TFC and mean TFC of LAD,LCX,and RCA in the observation group were higher than those in the control group(P＜0.05).(3)Multivariate Logistic regression analysis suggested that serum MAO and sST2 were independent risk factors for the occurrence of CSF(OR＞1,P＜0.05).(4)Pearson correlation a-nalysis showed that serum MAO and sST2 levels were positively correlated with the TFC of the LAD,LCX,and RCA,as well as the mean TFC(r=0.735,0.710,0.728,0.703,r=0.727,0.669,0.684,0.705,P＜0.05).(5)ROC curve revealed that the area under the curve(AUC)for predicting CSF was 0.761 of MAO,0.750 of sST2,and 0.807 of their combination.(6)DCA curve showed that the net benefit of serum MAO was greater than 0 when the threshold probability was between 0.05 and 0.70,the net benefit of serum sST2 was greater than 0 when the threshold probability was between 0.05 and 0.85,and their combined prediction yielded a greater net benefit within the threshold range of 0.40 to 0.90.Conclusion Elevated serum MAO and sST2 levels are independent risk factors for CSF.Both markers have good predictive value for CSF,and their combined detec-tion further improves predictive performance and clinical net benefit.
