Research progress on macrophages and tumor ferroptosis
10.3969/j.issn.1673-4130.2025.09.019
- VernacularTitle:巨噬细胞与肿瘤铁死亡的研究进展
- Author:
Fang LIU
1
;
Tingting FAN
;
Xiaoxia MA
;
Qinglin LIU
;
Che CHEN
Author Information
1. 甘肃中医药大学,甘肃兰州 730000
- Keywords:
macrophages;
tumor;
tumor microenvironment;
ferroptosis;
iron metabolism
- From:
International Journal of Laboratory Medicine
2025;46(9):1121-1125
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are closely related to tumor progression,and can promote tumor growth and pro-liferation by promoting inflammation,angiogenesis and immunosuppression and so on,as well as killing tumors by directly killing tumor cells and triggering specific immune responses.Iron death,as an iron-depend-ent cell death caused by lipid peroxidation,can effectively kill tumor cells when regulated from the perspective of iron homeostasis,and can also release pro-inflammatory factors,trigger inflammatory reactions,change the survival environment of tumors as well as reduce the immune susceptibility of tumor cells.In recent years,more and more studies have shown that macrophages and iron death are closely related.In this paper,the rela-tionship between macrophages and iron death in terms of their functional properties and targeting of tumors are mainly introduced,and an overview of the functional properties of the two differentiated phenotypes of macrophages for the treatment of iron death in tumors is provided.
