Prognostic value of serum Ghrelin,ANGPTL4 combined with Geriatric Nutritional Risk Index in elderly patients with chronic pulmonary heart disease
10.3969/j.issn.1673-4130.2025.09.005
- VernacularTitle:血清Ghrelin、ANGPTL4联合老年营养风险指数对老年慢性肺心病患者的预后预测价值
- Author:
Jun XUE
1
;
Jingjing YU
;
Mingyue XUE
;
Xiaolong LI
Author Information
1. 江苏省海安市人民医院呼吸与危重症医学科,江苏海安 226600
- Keywords:
growth hormone releasing peptide;
angiopoietin like protein 4;
elderly;
chronic pulmona-ry heart disease;
prognosis;
prediction
- From:
International Journal of Laboratory Medicine
2025;46(9):1046-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic value of serum growth hormone releasing peptide(Ghre-lin),angiopoietin like protein 4(ANGPTL4)combined with Geriatric Nutritional Risk Index(GNRI)in eld-erly patients with chronic pulmonary heart disease(CPHD).Methods From January 2019 to January 2022,a total of 98 elderly patients with CPHD admitted to the Hai'an People's Hospital were selected as the CPHD group,and another 98 healthy individuals who underwent physical examinations were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to determine the levels of serum Ghrelin and ANGPTL4.Multivariate Logistic regression was applied to analyze the influencing factors of prognosis in elderly patients with CPHD.Receiver operating characteristic(ROC)curve was plotted to analyze the predic-tive value of serum Ghrelin,ANGPTL4 combined with GNRI in the prognosis of CPHD.Results Compared with the control group,the level of serum Ghrelin and GNRI in the CPHD group were obviously reduced(P＜0.05),while the level of ANGPTL4 was obviously increased(P＜0.05).Compared with the survival group,the GNRI and Ghrelin level in the death group were obviously reduced(P＜0.05),while the level of AN-GPTL4 was obviously increased(P＜0.05).Multivariate Logistic regression results showed that ANGPTL4 was a risk factor affecting the prognosis of elderly CPHD patients(P＜0.05),while Ghrelin and GNRI were protective factors affecting the prognosis of elderly CPHD patients(P＜0.05).ROC curve results showed that the combination of serum Ghrelin,ANGPTL4,and GNRI had the largest area under the curve(AUC)in predicting the prognosis of elderly CPHD patients,which was better than that of the individual predictions of serum Ghrelin,ANGPTL4,and GNRI(P＜0.05).Conclusion The level of serum Ghrelin decreases and the level of ANGPTL4 increases in elderly patients with CPHD.The combination of the two with GNRI could better predict the prognosis of CPHD patients and has high predictive value.
