Value of combined prediction of peripheral blood CD4+,CD3-CD16+CD56+,CD8+,CD19+for survival outcome in patients with EBV infection-associated hemophagocytic syndrome
10.3969/j.issn.1673-4130.2025.08.016
- VernacularTitle:外周血CD4+、CD3-CD16+CD56+、CD8+、CD19+联合预测EBV感染相关噬血细胞综合征患者生存结局的价值
- Author:
Zhe PENG
1
;
Pei XING
;
Chenlu WANG
;
Wenjie YU
;
Yuli JIA
Author Information
1. 首都医科大学附属北京友谊医院检验科,北京 101400
- Keywords:
Epstein-Barr virus-associated hemophagocytic syndrome;
hemoglobin;
platelet count;
survival outcome
- From:
International Journal of Laboratory Medicine
2025;46(8):982-986,991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of combined prediction of peripheral blood CD4+,CD3-CD16+CD56+,CD8+,CD19+for the risk of death in patients with Epstein-Barr virus-associated hemophagocytic syn-drome(EBV-HLH).Methods A total of 84 patients with EBV-HLH who were treated in Beijing Friendship Hospital Affiliated to Capital Medical University and Peking University First Hospital from May 2021 to A-pril 2023 were selected and divided into a death group(17 cases)and a survival group(67 cases)according to their survival outcomes within 6 months.The general information and peripheral blood T lymphocyte subsets of the two groups were compared,multivariate Logistic regression analysis was conducted to investigate the influencing factors of death in EBV-HLH patients,and receiver operating characteristic(ROC)curve was used to evaluate the predictive value of peripheral blood T lymphocyte subsets on death in EBV-HLH patients.Results The platelet count,hemoglobin,CD4+and CD3-CD16+CD56+levels in the death group were lower than those in the survival group,while the levels of CD8+and CD19+were higher than those in the survival group(P＜0.05).Multivariate Logistic regression analysis showed that platelet count,hemoglobin,CD4+,and CD3-CD16+CD56+were all independent protective factors for the death of EBV-HLH patients,while CD8+and CD19+were independent risk factors for the death of EBV-HLH patients(P＜0.05).The ROC curve results showed that the area under the curve of combined prediction of CD4+,CD8+,CD19+,CD3 CD16+CD56+for death in EBV-HLH patients was 0.923,with sensitivity and specificity of 94.12％and 80.60％,respectively,which were significantly higher than those predicted by each individual indicator(P＜0.05).Conclusion The abnormal expression of CD4+,CD3-CD16+CD56+,CD8+,and CD19+in peripheral blood of EBV-HLH patients is associated with their survival outcomes,and the combined prediction of CD4+,CD3-CD16+CD56+,CD8+,and CD19+has high reference value for predicting patients'death.
