Value of cerebral cord blood flow ultrasound combined with glucose metabolism indexes in the diagnosis of preeclampsia with fetal growth restriction
10.3969/j.issn.1673-4130.2025.08.014
- VernacularTitle:脑脐血流超声联合糖代谢指标诊断子痫前期合并胎儿生长受限患者的价值
- Author:
Xiaoyue ZHANG
1
;
Jingjing GAO
;
Xiaozheng LIU
;
Haixia GAO
Author Information
1. 承德市中心医院产科,河北承德 067000
- Keywords:
brain cord blood flow ultrasound index;
fasting insulin;
fasting blood glucose;
pre-eclampsia;
fetal growth restriction
- From:
International Journal of Laboratory Medicine
2025;46(8):971-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of brain cord blood flow ultrasound combined with glucose metabolism indexes in the patients with preeclampsia(PE)complicated with fetal growth restriction(FGR).Methods This study was a prospective cohort case-control study.A total of 198 PE patients admitted to the hospital from January 2017 to January 2022 were collected and divided into group A(PE patients com-plicated with FGR,101 cases)and group B(PE patients without FGR,97 cases)according to whether they were complicated with FGR.45 pregnant women with healthy prenatal examination in the hospital were se-lected as group C,and the differences of brain cord blood flow ultrasound indexes and glucose metabolism inde-xes among the three groups and the efficiency for diagnosing PE complicated with FGR were analyzed.Results Fast-ing blood glucose and fasting insulin levels in group A,group B and group C were gradually decreased(P＜0.05).The peak systolic flow velocity/peak diastolic flow velocity(S/D),resistance index(RI)and pulsatility index(PI)of middle cerebral artery(MCA)of fetus in group A,group B and group C increased gradually(P＜0.05).The levels of umbilical artery(UA)of fetus in group A,group B and group C decreased gradually(P＜0.05).The area under the curve of fasting insulin,fasting blood glucose,S/D,RI and PI of MCA,S/D,RI,PI of UA and the combined detection were 0.782,0.748,0.765,0.836,0.805,0.758,0.811,0.795 and 0.895,respectively.The diagnostic efficiency of combined detection was higher than that of single diagnosis(Z=4.327,4.862,4.551,3.400,3.946,4.679,3.742,4.102,P＜0.05).Conclusion The combined detection of glucose metabolism indexes and brain cord blood flow ultrasound indexes is of great value in the differential diagnosis of patients with PE complicated with FGR,and has good clinical application value.
