Value of abnormal expression of serum alpha fetoprotein variant 3 and β2 microglobulin in predicting complications after interventional surgery in patients with liver cancer
10.3969/j.issn.1673-4130.2025.08.005
- VernacularTitle:血清甲胎蛋白异质体3和β2微球蛋白异常表达预测肝癌患者介入治疗术后并发症的价值
- Author:
Liangliang MA
1
;
Kai HUANG
;
Li LI
;
Dongxiao REN
;
Shujian GAO
;
Shenming DONG
Author Information
1. 山东大学齐鲁医院德州医院肿瘤介入科,山东德州 253000
- Keywords:
interventional surgery for liver cancer;
postoperative complications;
alpha fetoprotein vari-ant 3;
β2 microglobulin;
predictive value
- From:
International Journal of Laboratory Medicine
2025;46(8):921-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of abnormal expression of serum alpha fetoprotein variant 3(AFP-L3)and β2 microglobulin(β2-MG)in predicting complications after interventional surgery in patients with liver cancer.Methods Clinical information of totally 92 patients with liver cancer who underwent inter-ventional surgery in the hospital from January 2020 to December 2023 were retrospectively collected and the patients were divided into complication group(33 cases)and non-complication group(59 cases)according to whether complications occurred after interventional surgery.The levels of AFP-L3 and β2-MG were detected respectively.Multivariate Logistic regression was used to analyze the the factors influencing the occurrence of complications in patients with liver cancer.Receiver operating characteristic(ROC)curve was used to evaluate the val-ue of the levels of AFP-L3 and β2-MG to predict complications in patients with liver cancer.Results Compared with the non-complication group,the proportion of patients with a history of diabetes,positive hepatitis B vi-rus(HBV)-DNA,poorly differentiated histology,and the levels of AFP-L3 and β2-MG were higher in the complication group(P＜0.05),and the course of liver cancer was longer(P＜0.05).Multivariate Logistic re-gression analysis showed that the levels of AFP-L3 and β2-MG were independent risk factors for complications after interventional surgery in patients with liver cancer.The area under the curve(AUC)of AFP-L3 and β2-MG levels in predicting complications after interventional surgery in patients with liver cancer were 0.874 and 0.854,respectively,with sensitivity of 89.77％and 74.79％,and specificity of 87.21％and 84.82％,respec-tively.The cut off values were 92.281 μg/L and 4.430 mg/L,respectively.The AUC of the combination of AFP-L3 and β2-MG levels in predicting postoperative complications was 0.910,which was significantly better than the predictive value of the single indicator(P＜0.05).Conclusion High levels of serum AFP-L3 and β2-MG may be independent risk factors for complications after interventional surgery in patients with liver canc-er.The combined detection of the two serum indicators has higher predictive value for postoperative complica-tions.It provides a new means to evaluate complications in patients with liver cancer after interventional sur-gery.
