Value of ITGAM and ITGB2 levels in peripheral blood mononuclear cells in the diagnosis and prognosis evaluation for patients with severe acute pancreatitis complicated with acute lung injury
10.3969/j.issn.1673-4130.2025.08.002
- VernacularTitle:外周血单个核细胞中ITGAM、ITGB2水平在重症急性胰腺炎患者并发急性肺损伤诊断及预后评估中的价值
- Author:
Xianbiao XU
1
;
Jie SHAO
;
Mingfang YANG
;
Ruidan LI
;
Yaqin WANG
;
Li ZHANG
Author Information
1. 兵器工业总医院呼吸与危重症医学科,陕西西安 710065
- Keywords:
severe acute pancreatitis;
acute lung injury;
integrin subunit αM;
integrin subunit β2;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(8):904-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of integrin subunit αM(ITGAM)and integrin subunit β2(ITGB2)levels in peripheral blood mononuclear cells(PBMC)in the diagnosis and prognosis evaluation for patients with severe acute pancreatitis(SAP)complicated with acute lung injury(ALI).Methods A total of 205 patients with SAP admitted from November 2022 to February 2024 in the hospital were selected,and they were divided into ALI group(103 cases)and non-ALI group(102 cases)according to whether they were com-plicated with ALI.Meanwhile,110 healthy people who underwent the physical examination were selected as the control group.The differences of the levels of ITGAM and ITGB2 in PBMC in different groups were com-pared.Logistic regression was used to analyze the influencing factors for ALI in patients with SAP.The re-ceiver operating characteristic(ROC)curve was used to analyze the diagnostic value of levels of ITGAM and ITGB2 in PBMC for SAP patients complicated with ALI and the predictive value for poor prognosis.Results The levels of ITGAM,ITGB2 in PBMC,and serum amylase and urine amylase levels in ALI group were higher than those in non-ALI group and control group(P＜0.05).Multivariate Logistic regression anal-ysis showed that the increase of ITGAM,ITGB2 and serum amylase levels were risk factors for ALI in pa-tients with SAP(P＜0.05).ROC curve results showed that the area under the curve(AUC)of ITGAM com-bined with ITGB2 in diagnosing ALI in patients with SAP was significantly higher than those of ITGAM and ITGB2 alone(P＜0.05).The levels of ITGAM and ITGB2 in PBMC in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).ROC curve results showed that the AUC of ITGAM com-bined with ITGB2 in predicting poor prognosis in patients with SAP complicated with ALI was significantly higher than those of ITGAM and ITGB2 alone(P＜0.05).Conclusion Increased levels of ITGAM and IT-GB2 in PBMC are risk factors for ALI in patients with SAP.ITGAM combined with ITGB2 has a good predic-tive efficacy for the poor prognosis in patients with SAP complicated with ALI,which has important value in clinical practice and is expected to become potential biomarkers.
