Serum levels of MRP8/14 and Gal-13 in patients with acute exacerbation of chronic obstructive pulmonary disease and their clinical significance
10.3969/j.issn.1673-4130.2025.08.001
- VernacularTitle:慢性阻塞性肺疾病急性加重期患者血清MRP8/14、Gal-13水平及其临床意义
- Author:
Jue WANG
1
;
Xudong WANG
;
Ruihao WANG
Author Information
1. 黑龙江省第三医院重症医学科,黑龙江北安 164000
- Keywords:
acute exacerbation of chronic obstructive pulmonary disease;
myeloid-related protein 8/14;
galec-tin-13;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(8):897-903,909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the levels and clinical significance of serum myeloid-related protein 8/14(MRP8/14)and galectin(Gal)-13 in patients with acute exacerbation of chronic obstructive pulmonary dis-ease(AECOPD).Methods A total of 103 AECOPD patients who were admitted to the hospital from Febru-ary 2021 to February 2024 were collected as AECOPD group,and were divided into mild group(n=37),mod-erate group(n=45),severe group(n=21)according to the degree of disease,and the patients also were di-vided into good prognosis group(n=66)and poor prognosis group(n=37)according to prognosis of 28 d of admission to the hospital.During the same period,a total of 70 patients with stable chronic obstructive pulmo-nary disease(SCOPD)were selected as SCOPD group,and 70 healthy individuals who underwent the physical examination were selected as control group.Serum MRP8/14 and Gal-13 levels were measured by enzyme-linked immunosorbent assay,and lung function was examined by lung function detection instrument.Pearson product moment correlation or Spearman rank correlation was used to analyze correlation between serum MRP8/14,Gal-13 and degree of disease,lung function indexes in the AECOPD patients.Multivariate Logistic regression was used to analyze the factors influencing poor prognosis in the AECOPD patients.Receiver oper-ating characteristic curve was used to assess predictive value of serum MRP8/14 and Gal-13 for poor prognosis in the AECOPD patients.Results Compared with the control group,serum MRP8/14 and Gal-13 levels were increased in the AECOPD group and the SCOPD group(P＜0.05),and serum MRP8/14 and Gal-13 levels in the AECOPD group were higher than those in the SCOPD group(P＜0.05).Compared with the control group,first second forced expiratory volume(FEV1),percentage of FEV1 to expected value(FEV1％),forced vital capacity(FVC),percentage of FVC to expected value(FVC％)and FEV1/FVC were decreased in the AECOPD group and the SCOPD group(P＜0.05),and FEV1,FEV1％,FVC,FVC％,and FEV1/FVC in the AECOPD group were lower than those in the SCOPD group(P＜0.05).Serum MRP8/14 and Gal-13 levels in the AECOPD patients were positively correlated with degree of disease(P＜0.05),and negatively correlated with FEV1,FEV1％,FVC,FVC％,FEV1/FVC(P＜0.05).Age,MRP8/14 and Gal-13 were risk factors for poor prognosis in the AECOPD patients(OR=1.390,1.586,1.471,P＜0.05),and FEV1/FVC was a protec-tive factor for poor prognosis in the AECOPD patients(OR=0.752,P＜0.05).The area under the curve of serum MRP8/14,Gal-13 and the combination of the two for predicting poor prognosis in AECOPD patients were 0.850,0.846 and 0.931,respectively.The predictive value of the combination of the two was greater than that of single indicator,respectively(Z=1.866,1.881,P＜0.05).Conclusion The expression of serum MRP8/14 and Gal-13 are up-regulated in AECOPD patients,which are closely correlate with degree of disease and lung func-tion.Early combined detection of two indicators could predict the prognosis in AECOPD patients.
