Relationship between abnormal expression of serum NGB and MBP and the cerebral neurodevelopment of neonates with HIE
10.3969/j.issn.1673-4130.2025.07.006
- VernacularTitle:血清NGB和MBP异常表达与HIE患儿脑神经发育的关系研究
- Author:
Bihai HE
1
;
Nini ZHANG
;
Nannan SHI
;
Caihong SONG
;
Zhaoping HE
;
Xin LI
Author Information
1. 西安交通大学第一附属医院榆林医院:儿科,陕西 榆林 719000
- Keywords:
neurohemoglobin;
myelin basic protein;
hypoxic-ischemic encephalopathy;
cerebral neu-rodevelopment
- From:
International Journal of Laboratory Medicine
2025;46(7):796-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between abnormal expression of serum neurohemoglobin(NGB)and myelin basic protein(MBP)and the cerebral neurodevelopment of neonates with hypoxic-ischemic encephalopathy(HIE).Methods A total of 89 preterm infants with HIE admitted in the hospital between January 2023 and March 2024 were selected as the observation group,and 60 preterm infants without HIE during the same period were selected as the control group.Serum levels of MBP,NGB and secretagogues in two groups were detected,and the neonates amplitude integration electroencephalogram score was evaluated.The neurological function of neonates was evaluated using 20 items of Neonatal Behavioral Neurological As-sessment(NBNA).The correlation test and diagnostic value were evaluated using Spearman method and re-ceiver operating characteristic(ROC)curve.Results The serum levels of NGB,MBP and secretagogue in the ob-servation group were higher than those in the control group(P<0.05),and the amplitude integration electroencepha-logram score was lower than that in the control group(P<0.05).The serum MBP,NGB and secretagogue levels in the mild,moderate,and severe groups increased sequentially(P<0.05),NBNA score and amplitude integration e-lectroencephalogram score decreased sequentially(P<0.05).The levels of NGB,MBP and secretagogue were the risk factors affecting NBNA score(P<0.05),and the amplitude integration electroencephalogram score was a protective factor affecting NBNA score(P<0.05).The area under the curve of NGB and MBP in diag-nosing HIE was greater than 0.8,which had high application value.Conclusion Serum NGB and MBP levels are closely related to the severity of HIE,and have certain connection with NBNA score.Elevated levels of NGB and MBP in neonates with HIE may be related to the body's stress response to nerve damage,which could reflect to some extent the brain nerve function damage in with HIE.
