Relationship between bile acid sub components and traditional biochemical indicators and nonalcoholic fatty liver
10.3969/j.issn.1673-4130.2025.07.004
- VernacularTitle:非酒精性脂肪肝患者血清胆汁酸亚组分的研究
- Author:
Jinlong DU
1
;
Haoyu ZHANG
;
Zhendong LIU
;
Shumei LIU
;
Haiyan DU
;
Chunyan TANG
;
Zhuomin LI
;
Yanguo TAN
Author Information
1. 首都医科大学附属复兴医院检验科,北京 100038
- Keywords:
liquid chromatography tandem mass spectrometry;
bile acid subcomponent;
nonalcoholic fatty liver;
body mass index
- From:
International Journal of Laboratory Medicine
2025;46(7):786-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of 22 bile acid sub components and 17 traditional bio-chemical indicators in serum of patients with non-alcoholic fatty liver disease(NAFLD),and the diagnostic value of detecting the above indicators alone or in combination for NAFLD.Methods A total of 168 NAFLD patients(NAFLD group)and 216 non-NAFLD apparently healthy individuals(non-NAFLD group)were se-lected,bile acid sub components were determined by liquid chromatography tandem mass spectrometry,and traditional biochemical indicators were detected by automatic biochemical analyzer.Results There were sta-tistically significant differences in the levels of 12 bile acid sub components and 12 traditional biochemical indi-cators between NAFLD group and non-NAFLD group(P<0.05).Compared to traditional biochemical indica-tors,bile acid sub components were less affected by body mass index(BMI).The area under the curve for di-agnosing NAFLD by combining three bile acid sub components[taurocholic acid(TCA),sodium taurodeoxy-cholate(TDCA),and tauroursodeoxycholic acid(UDCA)]with three traditional biochemical indicators[ala-nine aminotransferase(ALT),5'Nucleotidase(5'-NT),and small and dense low-density lipoprotein cholester-ol(sd-LDL-C)]was the largest,which was 0.810.Conclusion Twelve kinds of bile acid sub components in the blood of NAFLD patients have changed,and the combined detection of bile acid sub components and tradi-tional biochemical indicators could improve the diagnostic efficacy of NAFLD to a certain extent.
