Diagnostic of combined detection of serum Endocan and NT-proBNP in pregnancy complicated with pulmonary hypertension
10.3969/j.issn.1673-4130.2025.06.020
- VernacularTitle:血清Endocan、NT-proBNP联合检测对妊娠合并肺动脉高压的诊断意义
- Author:
Guixin PENG
1
;
Wenli WANG
Author Information
1. 常州市妇幼保健院:重症医学科,江苏 常州 213000
- Keywords:
pulmonary hypertension;
pregnancy;
endothelium-specific molecule-1;
N-terminal pro-B-type natriuretic peptide
- From:
International Journal of Laboratory Medicine
2025;46(6):748-751,756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum endothelium-specific molecule-1(Endocan)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels in early prediction and disease evaluation of preg-nancy complicated with pulmonary hypertension(PH).Methods From March 2021 to March 2024,107 preg-nant women with dyspnea,palpitation and other symptoms during pregnancy in this hospital were selected as subjects.According to the results of echocardiography,the patients were divided into PPH group(62 cases)and control group(45 cases),and the relevant clinical data were collected.According to the pulmonary artery pressure measured by echocardiography during pregnancy,PPH group was divided into mild PPH group(35 cases),moderate PPH group(16 cases)and severe PPH group(11 cases).The levels of serum Endocan and NT-proBNP and the incidence of adverse events in each group were compared.The predictive value of Endocan and NT-proBNP for pregnancy complicated with PH was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the mild,moderate and severe PPH groups had significant increases in Endocan and NT-proBNP levels(P<0.05).The ROC curve showed that Endocan≥9.07 ng/mL had a sensitivity of 65.7%and a specificity of 91.1%in predicting pregnancy complicated with PH.When NT-proBNP≥51.90 pg/mL,the sensitivity and specificity of predicting pregnancy complicated with PH were 54.3%and 68.9%,respectively.The sensitivity and specificity of Endocan combined with NT-proBNP in pre-dicting pregnancy complicated with PH were 80.0%and 80.0%,respectively.The incidences of heart failure,intensive care unit admission,iatrogenic abortion and preterm birth were significantly higher in the severe PPH group than in the mild and moderate PPH groups(P<0.05).Conclusion The increase of serum En-docan and NT-proBNP levels is related to the occurrence of pregnancy complicated with PH.The detection of serum Endocan and NT-proBNP levels can assist the early prediction of pregnancy complicated with PH and the evaluation of disease severity.
