Relationship between serum dp-ucMGP,OSMR,CTRP15 and the degree of coronary artery disease and in-stent restenosis after PCI in patients with acute coronary syndrome
10.3969/j.issn.1673-4130.2025.06.019
- VernacularTitle:血清dp-ucMGP、OSMR、CTRP15与急性冠脉综合征患者冠状动脉病变程度及PCI术后支架内再狭窄的关系
- Author:
Wenjuan DUAN
1
;
Baojun REN
Author Information
1. 内蒙古医科大学新华校区医务所,内蒙古 呼和浩特 010030
- Keywords:
dephosphorylated uncarboxylated matrix Gla protein;
oncostatin receptor;
C1q tumor nec-rosis factor-related protein 15;
acute coronary syndrome;
percutaneous coronary intervention;
in-stent restenosis
- From:
International Journal of Laboratory Medicine
2025;46(6):742-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum dephosphorylated uncarboxylated ma-trix Gla protein(dp-ucMGP),oncostatin receptor(OSMR),C1q tumor necrosis factor-related protein 15(CTRP15)and the degree of coronary artery disease and in-stent restenosis after percutaneous coronary inter-vention(PCI)in patients with acute coronary syndrome(ACS).Methods A total of 162 ACS patients who underwent PCI in this hospital from January 2021 to January 2023 were selected as the research objects.Ac-cording to the degree of coronary artery disease,the patients were divided into low lesion group(n=48),me-dium lesion group(n=80)and high lesion group(n=34).According to follow-up records,the patients were divided into stenosis group(n=40)and non-stenosis group(n=122).Serum dp-ucMGP,OSMR and CTRP15 levels were detected,and general clinical data were collected and analyzed in ACS patients.Multivariate Logis-tic regression was used to analyze the influencing factors of in-stent restenosis after PCI.The receiver operat-ing characteristic(ROC)curve was drawn to analyze the predictive value of dp-ucMGP,OSMR and CTRP15 for in-stent restenosis after PCI.Results Compared with the low lesion group,the serum levels of dp-ucMGP in the medium lesion group and the high lesion group were increased(P<0.05),while the levels of OSMR and CTRP15 were decreased(P<0.05).Compared with the medium lesion group,the serum level of dp-uc-MGP in the high lesion group was increased(P<0.05),while the levels of OSMR and CTRP15 were de-creased(P<0.05).The lesion length,preoperative stenosis degree,stent length and serum troponin I,N-ter-minal pro-B-type natriuretic peptide,C-reactive protein(CRP),dp-ucMGP levels in stenosis group were higher than those in non-stenosis group(P<0.05),while OSMR and CTRP15 levels were lower than those in non-stenosis group(P<0.05).The area under the curve(AUC)of dp-ucMGP,OSMR and CTRP15 alone and in combination for predicting in-stent restenosis after PCI was 0.839,0.849,0.838 and 0.922,respectively.The AUC of combined prediction was higher than that of dp-ucMGP(Z=2.304,P=0.021),OSMR(Z=2.073,P=0.038),and CTRP15(Z=2.414,P=0.016)alone.Stent length and CRP,dp-ucMGP levels were risk fac-tors for in-stent restenosis,while CTRP15 and OSMR levels were protective factors(P<0.05).Conclusion In ACS patients with in-stent restenosis after PCI,serum dp-ucMGP level is increased,and OS-MR and CTRP15 levels are decreased,which are related to the degree of coronary artery disease and in-stent restenosis after PCI,and have certain auxiliary predictive value for in-stent restenosis after PCI.
