Changes and clinical significance of SDF-1,MCP-1 and sCD44 levels in aqueous humor of patients with diabetic cataract
10.3969/j.issn.1673-4130.2025.06.010
- VernacularTitle:糖尿病性白内障患者房水SDF-1、MCP-1及sCD44水平变化及其临床意义
- Author:
Xiaoyu QU
1
;
Hongna ZHU
;
Anle SU
;
Huiqin LU
;
Bing WANG
Author Information
1. 西安市第一医院眼科,陕西 西安 710002
- Keywords:
diabetic cataract;
aqueous humor;
stromal cell-derived factor-1;
macrophage chemoat-tractant protein-1;
soluble adhesion molecule CD44
- From:
International Journal of Laboratory Medicine
2025;46(6):694-697,703
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes and clinical significance of aqueous humor stromal cell-de-rived factor-1(SDF-1),macrophage chemoattractant protein-1(MCP-1)and soluble adhesion molecule CD44(sCD44)in patients with diabetic cataract(DC).Methods A total of 80 patients with DC admitted to the hos-pital from January 2021 to January 2023 were selected as the DC group,and 40 patients with simple cataract during the same period were selected as the age-related cataract group.According to the stage of cataract,DC patients were divided into group A(incipient stage,32 cases),group B(intumescent stage,26 cases)and group C(mature stage and over mature stage,22 cases).According to the presence or absence of macular ede-ma after treatment,the patients were divided into occurrence group(20 cases)and non-occurrence group(60 cases).The levels of SDF-1,MCP-1 and sCD44 in each group were detected by enzyme-linked immunosorbent assay.The receiver operating characteristic curve and area under the curve(AUC)were used to analyze the value of SDF-1,MCP-1 and sCD44 levels in the diagnosis of DC.Results The levels of SDF-1,MCP-1 and sCD44 in the DC group were higher than those in the age-related cataract group(P<0.05),and the levels of SDF-1,MCP-1 and sCD44 in the A,B and C groups increased sequentially(P<0.05).The level of MCP-1 in the occurrence group was higher than that in the non-occurrence group(P<0.05).The AUC of MCP-1,sCD44 and SDF-1 in the diagnosis of DC was 0.869,and the diagnostic efficiency was better.Conclusion The changes of aqueous SDF-1,MCP-1 and sCD44 levels are related to the stage of cataract in DC patients.Dynam-ic monitoring of these three indexes,especially MCP-1,is helpful to judge the condition and prognosis of DC patients.
