Value of combined detection of ApoA2,C1INH,and ALB in the screening of stage Ⅰ-Ⅲ colorectal cancer
10.3969/j.issn.1673-4130.2025.06.006
- VernacularTitle:ApoA2、C1INH和ALB联合检测在Ⅰ～Ⅲ期结直肠癌筛查中的价值
- Author:
Yazhou WU
1
;
Runhao XU
;
Jie ZHANG
;
Yun CAO
;
Hanhua LI
;
Bing ZHENG
Author Information
1. 上海交通大学医学院附属仁济医院检验科,上海 200001;上海市杨浦区中心医院检验科,上海 200093
- Keywords:
colorectal cancer;
blood lipids;
complement;
albumin;
Fisher discriminant model
- From:
International Journal of Laboratory Medicine
2025;46(6):670-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of 8 lipid biomarkers,4 complement biomarkers and albu-min(ALB)in serum of patients with colorectal cancer(CRC)and their value in CRC screening.Methods A total of 120 newly diagnosed CRC patients in Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine from August 2022 to January 2024 were selected as the CRC group,and 110 healthy subjects were selected as the healthy control(HC)group.A total of 8 lipid biomarkers including total cholesterol(TC),tri-glyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein(Apo)A1,ApoA2,ApoB and ApoE,4 complement biomarkers including complement C3(C3),complement C4(C4),complement C1q(C1q)and complement C1 inhibitor(C1INH),3 intestinal tumor markers including carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,CA19-9,and ALB levels were detected in serum of each group.Independent sample t test and Mann-Whitney U test were used for com-parison between groups,and stepwise Fisher discriminant algorithm was used to fit each marker to establish a screening model.Receiver operating characteristic curve was used to analyze the diagnostic efficacy of each marker and the model.Results The serum levels of ApoA1,ApoA2,HDL-C,TC and ALB in CRC group were lower than those in HC group(P<0.05),while the serum levels of C1INH,C4 and CEA were higher than those in HC group(P<0.05).Among the single biomarkers,ALB had the highest diagnostic efficiency,the area under the curve(AUC)was 0.909,the sensitivity was 77.50%,and the specificity was 94.55%.The AUC of the screening model composed of ApoA2,C1INH and ALB was 0.978,the sensitivity was 91.67%,and the specificity was 98.86%.The diagnostic efficacy was higher than any single biomarker.Conclusion ApoA2,C1INH and ALB are abnormally expressed in the serum of CRC patients.The screening model composed of ApoA2,C1INH and ALB can provide reference for CRC screening and clinical auxiliary diagnosis.
