Epidemiology and risk factors for mortality in patients with postcraniotomy meningitis caused by Gram-negative bacteria
10.3969/j.issn.1673-4130.2025.06.005
- VernacularTitle:革兰阴性菌导致的开颅术后脑膜炎患者的流行病学与死亡风险因素研究
- Author:
Siqi WANG
1
;
Guanghui ZHENG
;
Yijun SHI
;
Jialu SUN
;
Hong LYU
;
Guojun ZHANG
Author Information
1. 首都医科大学附属北京天坛医院实验诊断中心,北京 100070
- Keywords:
epidemiology;
postcraniotomy meningitis;
risk factors;
Gram-negative bacteria
- From:
International Journal of Laboratory Medicine
2025;46(6):664-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiological characteristics of patients with postcraniotomy meningitis(PM)caused by Gram-negative bacteria(GNB),and to evaluate the related risk factors for mortal-ity.Methods A total of 202 PM patients in Beijing Tiantan Hospital,Capital Medical University from May 2019 to December 2021 were retrospectively analyzed,including 54 cases in the death group and 148 cases in the survival group.The distribution of microorganisms in the two groups was analyzed,and Cox proportional hazards regression model was established to evaluate the risk factors of death.Results Among the 202 pa-tients with PM caused by GNB,with a mortality rate of 26.7%,Klebsiella pneumoniae(24.8%),Acinetobact-er baumannii(21.8%)and Escherichia coli(8.4%)were the top three isolated pathogens.The proportions of GNB distribution in the survival group and the death group were similar,but the bacteria distribution in the death group was more concentrate.Cox proportional hazards regression model results showed that hyperten-sion(HR=2.384,95%CI 1.229-4.626,P=0.010)and admission to ICU(HR=3.695,95%CI 1.412-9.670,P=0.008)were independent risk factors for death in patients with PM caused by GNB.Conclusion The mortality of PM caused by GNB is high.Hypertension and admission to ICU are independent risk factors for death of patients,and attention should be paid to prevention and treatment in clinical practice.
