Establishment of reference intervals for serum β-HCG in adult non-pregnant women in Shanghai
10.3969/j.issn.1673-4130.2025.05.017
- VernacularTitle:上海地区成年非妊娠女性血清β-HCG参考区间的建立
- Author:
Xiaoyan MA
1
;
Wenfang ZHUANG
;
Min CHU
Author Information
1. 上海理工大学附属市东医院检验科,上海 200438
- Keywords:
β-human chorionic gonadotropin;
adult non-pregnant;
reference interval
- From:
International Journal of Laboratory Medicine
2025;46(5):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the reference intervals of serum β-human chorionic gonadotropin(β-HCG)in adult non-pregnant women in Shanghai,and to explore its relationship with age.Methods A total of 854 non-pregnant women in the hospital from March 2021 to December 2023 were selected as the research ob-jects,and 800 women who met the criteria were finally included.All serum β-HCG levels were detected by magnetic particle enzyme immunoassay.The results of serum β-HCG in different age groups were statistically analyzed,and the reference intervals of each age group was calculated by one-sided 95%reference interval method.Results The distribution of serum β-HCG in non-pregnant women was not normal.Spearman corre-lation analysis showed that the median level of β-HCG was correlated with age(correlation coefficient was 0.859,P<0.05).The reference intervals established by percentile method were 0.00-3.03 mIU/mL 18-<41 years old.41-55 years old 0.00-4.61 mIU/mL,>55 years old 0.00-6.80 mIU/mL,respectively,the difference of serum β-HCG level between different age groups was statistically significant(P<0.05).Accord-ing to the literature review,the reference intervals of serum β-HCG in different laboratories were different.In this study,the appropriate reference intervals were established and verified according to the actual situation.Conclusion The reference intervals of serum β-HCG in adult non-pregnant women should be established ac-cording to their age,so as to provide scientific basis for clinical diagnosis and treatment.
