Diagnostic value of TGF-β1,S100-A8 and IL-17 in spinal tuberculosis and their relationship with ESR and CRP
10.3969/j.issn.1673-4130.2025.05.010
- VernacularTitle:TGF-β1、S100-A8、IL-17对脊柱结核的诊断价值及与ESR、CRP的关系
- Author:
Weiyuan XU
1
;
Wenkai WANG
Author Information
1. 兰州大学第二医院骨科,甘肃 兰州 730000
- Keywords:
spinal tuberculosis;
transforming growth factor-β1;
calgranulin A8;
interleukin-17;
erythrocyte sedimentation rate;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2025;46(5):558-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of transforming growth factor-β1(TGF-β1),cal-granulin A8(S100-A8)and interleukin-17(IL-17)in spinal tuberculosis and their relationship with erythro-cyte sedimentation rate(ESR)and C-reactive protein(CRP).Methods A total of 103 patients diagnosed with spinal tuberculosis in the Second Hospital of Lanzhou University from July 2017 to December 2023 were se-lected as the study group,and 109 healthy people were selected as the control group during the same period.The general data of the two groups were collected,and the levels of TGF-β1,S100-A8,IL-17,ESR and CRP were compared between the two groups.The receiver operating characteristic(ROC)curve was used to ana-lyze the diagnostic value of TGF-β1,S100-A8 and IL-17 for spinal tuberculosis.Pearson correlation analysis was used to study the correlation between the levels of TGF-β1,S100-A8,IL-17 and ESR,CRP in patients with spinal tuberculosis.Results The proportion of hypertension and tuberculosis in the study group was higher than that in the control group(P<0.05),and there was no significant difference in other indicators between the two groups(P>0.05).Compared with the control group,the levels of TGF-β1,S100-A8,IL-17,ESR and CRP in the study group were increased(P<0.05).The levels of TGF-β1,S100-A8 and IL-17 were positively correlated with ESR and CRP(P<0.05).ROC curve analysis showed that the area under the curve,sensitivi-ty and specificity of TGF-β1,S100-A8 and IL-17 in the diagnosis of spinal tuberculosis were 0.907,97.1%and 74.3%,respectively,and the diagnostic efficiency was high.Conclusion The combination of TGF-β1,S100-A8 and IL-17 has a better diagnostic efficacy,and it is positively correlated with ESR and CRP in patients with spinal tuberculosis.
