Relationship between serum IGFBP-3,GP73,CCSA-2 expression and clinicopathological features and prognosis in patients with colorectal cancer
10.3969/j.issn.1673-4130.2025.05.008
- VernacularTitle:结直肠癌患者血清IGFBP-3、GP73、CCSA-2表达与临床病理特征和预后的关系
- Author:
Xiuxia GAO
1
;
Le JIA
Author Information
1. 宝鸡高新医院病理科,陕西 宝鸡 721031
- Keywords:
colorectal cancer;
insulin-like growth factor binding protein-3;
Golgi transmembrane gly-coprotein 73;
colorectal cancer specific antigen-2;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(5):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum insulin-like growth factor binding protein-3(IGFBP-3),Golgi transmembrane protein 73(GP73)and colorectal cancer specific antigen-2(CCSA-2)in pa-tients with colorectal cancer(CRC)and their relationship with clinicopathological features and prognosis.Methods A total of 80 patients with CRC in Baoji High-tech Hospital and Baoji Hospital of Traditional Chi-nese Medicine from January 2019 to December 2020 were selected as the CRC group,and 80 healthy people in the same period were included as the control group.Serum levels of IGFBP-3,GP73 and CCSA-2 were detected by enzyme-linked immunosorbent assay.All patients were followed up for 3 years.Cox proportional hazards regression model was used to analyze the prognostic factors.Results The level of serum IGFBP-3 in CRC group was lower than that in control group,and the levels of GP73 and CCSA-2 were higher than those in con-trol group(P<0.05).The serum levels of IGFBP-3,GP73 and CCSA-2 were related to tumor size,differenti-ation degree,TNM stage and lymph node metastasis(P<0.05).The overall survival and progression-free survival rates of patients with high expression of IGFBP-3 and low expression of GP73 and CCSA-2 were sig-nificantly higher than those of patients with low expression of IGFBP-3 and high expression of GP73 and CC-SA-2(P<0.05).Tumor size,differentiation degree,TNM stage,lymph node metastasis and serum levels of IGFBP-3,GP73 and CCSA-2 were the influencing factors for the prognosis of CRC patients(P<0.05).Con-clusion The serum levels of IGFBP-3,GP73 and CCSA-2 are closely related to the clinicopathological charac-teristics and prognosis of CRC patients,and are expected to become important biological indicators for predic-ting and evaluating the prognosis of patients.They can provide certain reference for early diagnosis of disease,early detection of recurrence and metastasis,and evaluation and predicting the prognosis of patients.
