Relationship between serum PAI-1 and ANXA2 levels and carotid plaque stability in patients with transient ischemic attack
10.3969/j.issn.1673-4130.2025.05.007
- VernacularTitle:血清PAI-1、ANXA2水平与短暂性脑缺血发作患者颈动脉斑块稳定性的关系
- Author:
Quan ZHAO
1
;
Shide QIAN
;
Ziqi HU
;
Dongsheng JIAO
Author Information
1. 东部战区空军医院神经科,江苏 南京 210000
- Keywords:
transient ischemic attack;
plasminogen activator inhibitor-1;
annexin A2;
carotid athero-sclerosis stability
- From:
International Journal of Laboratory Medicine
2025;46(5):543-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of plasminogen activator inhibi-tor-1(PAI-1)and annexin A2(ANXA2)and the carotid atherosclerosis stability(CAS)plaque in patients with transient ischemic attack(TIA).Methods A total of 131 patients with TIA admitted to the hospital from January 2021 to January 2023 were selected as the TIA group,and 46 healthy people in the same period were selected as the control group.According to the CAS plaque stability of TIA patients,they were divided into unstable plaque group(64 cases)and stable plaque/no plaque group(67 cases).The serum levels of PAI-1 and ANXA2 were detected by enzyme-linked immunosorbent assay and chemiluminescence immunoassay,respectively.Multivariate Logistic regression analysis was used to analyze the factors of CAS plaque stability in TIA patients.Receiver operating characteristic curve was used to analyze the predictive value of serum PAI-1 and ANXA2 levels for CAS instability in TIA patients.Results Compared with the control group,the levels of PAI-1 and ANXA2 in TIA group were significantly increased(P<0.05).Compared with the stable plaque/no plaque group,the unstable plaque group was significant increaseed in the serum levels of PAI-1 and ANXA2(P<0.05).Smoking,high risk of TIA,elevated PAI-1 and ANXA2 were independent risk factors for CAS plaque stability in patients with TIA(P<0.05).The area under the curve predicted by serum PAI-1 and ANXA2 levels combined was 0.879,which was larger than 0.788 and 0.783 predicted by serum PAI-1 and ANXA2 levels alone(P<0.05).Conclusion The increased levels of serum PAI-1 and ANXA2 are closely re-lated to CAS plaque instability in patients with TIA.The combination of serum PAI-1 and ANXA2 levels has a higher value in predicting CAS plaque instability in patients with TIA.
