Establishment of reference interval for adult serum CA242 in Shanghai using indirect method
10.3969/j.issn.1673-4130.2025.05.005
- VernacularTitle:间接法建立上海地区成人血清CA242的参考区间
- Author:
Yafang PAN
1
;
Wenqi SHAO
;
Jing ZHU
;
Jing YANG
;
Baishen PAN
;
Beili WANG
;
Wei GUO
Author Information
1. 复旦大学附属中山医院检验科,上海 200032
- Keywords:
carbohydrate antigen 242;
indirect method;
reference interval
- From:
International Journal of Laboratory Medicine
2025;46(5):530-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the use of indirect methods to establish a reference interval for serum car-bohydrate antigen 242(CA242)in adults in Shanghai and to validate it.Methods A total of 51 897 cases of CA242 testing data from the laboratory information management system of the Department of Clinical Labo-ratory at the hospital from August 2022 to July 2023 were collected.After data cleaning and normal transfor-mation,the Turkey method was used to remove outliers,and 19 653 cases of data were finally included in the study.Then,the Hoffmann method was used to establish the P95 reference interval for serum CA242.The study selected 691 apparently healthy individuals from January to March 2024 to validate the self built refer-ence interval for CA242.The physical examination population with the reference interval recommended by the reagent instructions≤CA242 value
