Relationship between serum microRNA-214,ChE,albumin levels and prognosis of patients with acute organophosphate poisoning
10.3969/j.issn.1673-4130.2025.04.016
- VernacularTitle:血清miRNA-214、ChE、白蛋白水平与急性有机磷中毒患者预后的关系分析
- Author:
Shanmin JIN
1
;
Qing WEI
;
Shouren ZHU
Author Information
1. 宣城市中心医院急诊科,安徽宣城 242000
- Keywords:
micro ribonucleic acid-214;
cholinesterase;
albumin;
acute organophosphate poisoning;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(4):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between serum micro ribonucleic acid(miRNA)-214,cholinesterase(ChE),albumin(ALB)levels and the prognosis of patients with acute organophosphate poison-ing(AOPP).Methods A total of 160 patients with AOPP admitted to the hospital were enrolled as the re-search objects between June 2018 and December 2022.According to whether they were alive at 14 d after treatment,patients were divided into survival group(119 cases)and death group(41 cases).The relative ex-pression level of serum miRNA-214 was detected by fluorescence quantitative polymerase chain reaction,ChE level was detected by full-automatic biochemical analyzer,and level of serum ALB was detected by immuno-turbidimetry.The correlation between serum miRNA-214 and ChE,ALB in AOPP patients was analyzed by Pearson correlation analysis.The risk factors of prognosis in AOPP patients were analyzed by Logistic regres-sion analysis.The predictive efficiency of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,miRNA-214,ChE and ALB for prognosis was detected by receiver operating characteristic(ROC)curves.Results APACHE Ⅱ score and relative expression level of serum miRNA-214 in death group were significantly higher than those in survival group,while levels of ChE and ALB were significantly lower than those in survival group(P＜0.05).The results of Logistic regression analysis showed that miRNA-2143.75 and ChE＜931.92 U/L were all independent risk factors of poor prognosis in AOPP patients(P＜0.05).Pearson correlation analysis showed that miRNA-214 was not correlated with ChE and ALB in death group(r=-0.172,0.035,P＞0.05).The results of ROC curves showed that area under the curve(AUC)values of APACHE Ⅱ score,miRNA-214,ChE and ALB for predicting poor prognosis of AOPP patients were 0.777,0.933,0.805 and 0.881,respectively.Conclusion The serum miRNA-214,ChE and ALB levels are re-lated to prognosis of AOPP patients,which can be applied as important reference indexes to predict prognosis of AOPP patients.
