Analysis of serum INHB,AMH and sex hormone levels in patients with infertility caused by polycystic ovary syndrome
10.3969/j.issn.1673-4130.2025.04.015
- VernacularTitle:多囊卵巢综合征所致不孕症患者血清INHB、AMH及性激素水平检测分析
- Author:
Xiaolian LUO
1
;
Yongliang LI
Author Information
1. 青海省交通医院产科,青海西宁 810001
- Keywords:
polycystic ovary syndrome;
infertility;
anti-Müllerian hormone;
inhibin B;
sex hormone
- From:
International Journal of Laboratory Medicine
2025;46(4):462-465,470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of serum inhibin B(INHB),anti-Müllerian hormone(AMH)and sex hormone levels in patients with infertility caused by polycystic ovary syndrome(PCOS).Methods A total of 302 patients with infertility caused by PCOS admitted to the hospital from June 2021 to June 2023 were selected as the experimental group,and 300 healthy women of childbearing age with normal menstrual cycle were selected as the control group.The levels of serum INHB,AMH and sex hormone indexes[serum luteinizing hormone(LH),follicle stimulating hormone(FSH),prolactin(PRL),progesterone(P),testoster-one(T),estradiol(E2)]and homeostasis model assessment of insulin resistance(HOMA-IR)were observed and compared between the two groups.Results The serum levels of AMH,INHB and HOMA-IR in test group were significantly higher than those in control group,with statistical significance(P＜0.05).Serum levels of LH/FSH,PRL,T and P in experimental groups were significantly higher than those in control group,and serum E2 levels were significantly lower than those in control group,with statistical significance(P＜0.05).With the passage of treatment time,serum AMH,INHB,LH/FSH,PRL,T and P levels gradually decreased,and E2 levels gradually increased(P＜0.05).The area under the curve(AUC)of AMH and INHB combined detection in the diagnosis of infertility caused by PCOS was 0.905,which was higher than the AUC of AMH or INHB detection alone(P＜0.05).Serum AMH and INHB levels were positively correlated with FSH,LH,T and HOMA-IR,PRL,P(P＜0.05),and negatively correlated with serum E2 levels(P＜0.05).Conclusion The levels of AMH and INHB in serum of infertility patients caused by PCOS are significantly increased,and AMH and INHB are correlated with sex hormone levels.Detection of serum AMH,INHB and sex hormone levels is helpful for the diagnosis of infertility caused by PCOS.
