The value of serum and sputum Galectin-7 expression in evaluating the therapeutic effect of omalizumab in children with moderate asthma
10.3969/j.issn.1673-4130.2025.04.014
- VernacularTitle:血清和痰液Galectin-7表达对中度哮喘患儿奥马珠单抗治疗效果的评估价值
- Author:
Xiuya ZHANG
1
;
Wei HUANG
;
Ling LIU
;
Jiao CHEN
Author Information
1. 秦皇岛市第一医院儿科,河北秦皇岛 066000
- Keywords:
asthma;
omalizumab;
Galectin-7
- From:
International Journal of Laboratory Medicine
2025;46(4):457-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum and sputum Galectin-7 expression in evaluating the therapeutic effect of omalizumab in children with moderate asthma.Methods A total of 210 children with moderate asthma admitted to the hospital from January 2021 to August 2023 were selected as the study ob-jects.All the children were treated with omazumab,and the efficacy was evaluated according to the clinical control criteria of asthma,and they were divided into effective group and ineffective group.The expression of Galectin-7 in serum and sputum before treatment was detected in the two groups.Multivariate Logistic regres-sion was used to analyze the relationship between serum and sputum Galectin-7 and the efficacy of omalizumab in the treatment of moderate asthma children.Receiver operating characteristic(ROC)curve was used to ana-lyze the value of serum and sputum Galectin-7 in evaluating the efficacy of omalizumab in the treatment of children with moderate asthma.Results There was statistical significance in the proportion of passive smok-ing between the two groups(P＜0.05).The expression of Galectin-7 in serum and sputum before treatment in the effective group was lower than that in the ineffective group,and the difference was statistically signifi-cant(P＜0.05).Multivariate Logistic regression analysis showed that passive smoking history,serum Galec-tin-7 expression and sputum Galectin-7 expression were independent risk factors affecting the efficacy of oma-lizumab in the treatment of moderate asthma children(P＜0.05).ROC curve analysis results showed that,The area under the curve of serum Galectin-7,sputum Galectin-7 and their combination to evaluate the efficacy of omalizumab in the treatment of children with moderate asthma were 0.791(95％CI:0.673-0.849),0.845(95％CI:0.766-0.925),0.910(95％CI:0.844-0.976),respectively.Conclusion The combined detection of serum Galectin-7 and sputum Galectin-7 has a higher value in evaluating the therapeutic effect of omazumab in children with moderate asthma.
