The relationship between umbilical cord blood RANTES,CyPA and the occurrence of NBI in neonates delivered by puerperant women with premature rupture of membranes combined with intrauterine infection
10.3969/j.issn.1673-4130.2025.04.011
- VernacularTitle:脐血RANTES、CyPA与胎膜早破合并宫内感染产妇分娩的新生儿发生NBI的关系
- Author:
Yuanhui LIU
1
;
Xiaoling LI
Author Information
1. 湖北省孝感市妇幼保健院产科,湖北孝感 432100
- Keywords:
premature rupture of membrane;
intrauterine infection;
regulated upon activation normal T cell expressed and secreted;
cyclophilin A;
neonatal brain injury
- From:
International Journal of Laboratory Medicine
2025;46(4):443-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between umbilical cord blood regulated upon activa-tion normal T cell expressed and secreted(RANTES),cyclophilin A(CyPA)and neonatal brain injury(NBI)in neonates delivered by puerperant women with premature rupture of fetal membrane(PROM)and intrau-terine infection(IAI).Methods A total of 157 puerperant women with PROM and IAI who gave birth in the hospital from January 2022 to March 2024 were selected as the experimental group.Another 80 healthy partu-rients were selected as the control group.Neonates delivered by puerperant women with PROM and IAI were divided into NBI group(61 cases)and non-NBI group(96 cases)according to whether or not NBI occurred.The levels of RANTES and CyPA in umbilical cord blood were detected.NBI in neonates delivered by puerp-erant women with PROM and IAI was used as the dependent variable,and the influencing factors were deter-mined by multivariate Logistic regression analysis.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of umbilical cord blood RANTES and CyPA levels for NBI in neonates delivered by puerperant women with PROM and IAI.Results Compared with neonates delivered in control group,the levels of RANTES and CyPA in umbilical cord blood of neonates delivered in experimental group were in-creased,and the differences were statistically significant(P＜0.05).PROM type,1 min Apgar score,procalci-tonin(PCT),C-reactive protein,RANTES,CyPA were associated with NBI in the neonates delivered by puer-perant women with PROM and IAI(P＜0.05).The independent risk factors for NBI were increased Apgar score within 1 min(P＜0.05),and the independent protective factors were increased PCT,R ANTES and CyPA(P＜0.05).ROC curve analysis results showed that the area under the curve of umbilical cord blood RANTES and CyPA combined to predict the occurrence of NBI in neonates delivered by puerperant women with PROM and IAI was 0.874,which was larger than the 0.787 and 0.791 predicted by umbilical cord blood RANTES and CyPA alone(Z=3.248,2.801,P=0.001,0.005).Conclusion Umbilical cord blood RANTES and CyPA have high predictive efficacy for NBI in neonates delivered by puerperant women with PROM and IAI.
