Advances in serological markers associated with occult hepatitis B virus infection
10.3969/j.issn.1673-4130.2025.03.017
- VernacularTitle:隐匿性乙型肝炎病毒感染相关的血清学标志物的研究进展
- Author:
Lanxin PENG
1
;
Yu XIANG
Author Information
1. 重庆医科大学附属第一医院检验科,重庆 400016
- Keywords:
occult hepatitis B virus infection;
serological markers;
pathogenesis
- From:
International Journal of Laboratory Medicine
2025;46(3):340-344
- CountryChina
- Language:Chinese
-
Abstract:
With the advancement of hepatitis B virus(HBV)testing technology,it has been found that some patients are negative for hepatitis B virus surface antigen but positive for HBV deoxyribonucleic acid in liver or serum,and this particular type of infection is known as occult hepatitis B virus infection(OBI).The pathogenesis of OBI is mainly related to viral mutations,host immune response,epigenetics,and co-infection with hepatitis C virus.The clinical risks of OBI mainly include the spread of HBV,HBV reactivation in the presence of decreased body immunity,and hepatocarcinogenesis.The detection rate of OBI is relatively low due to the unique serum pattern,clinical manifestations and methodological limitations of some detection indica-tors of OBI.Therefore,there is an urgent need to find novel serologic markers to improve the detection rate of OBI and reduce the risk of HBV transmission.This article mainly focuses on the review of the research pro-gress of serological markers related to OBI.
