Application of genetic testing in psychotropic drug therapy
10.3969/j.issn.1673-4130.2025.03.016
- VernacularTitle:基因检测在精神药物治疗中的应用
- Author:
Qi GUO
1
;
Ling ZHANG
;
Yuan FENG
;
Sihai LING
;
Canjun RUAN
;
Wei GUO
;
Wenbiao LI
;
Chengeng LIU
;
Gang WANG
Author Information
1. 首都医科大学附属北京安定医院/国家精神疾病医学中心/国家精神心理疾病临床医学研究中心/精神疾病诊断与治疗北京市重点实验室,北京 100088;首都医科大学人脑保护高精尖创新中心,北京 100069
- Keywords:
psychotropic drug;
pharmacogenomics;
clinical application
- From:
International Journal of Laboratory Medicine
2025;46(3):335-339,344
- CountryChina
- Language:Chinese
-
Abstract:
Psychotropic medication plays a crucial role in the field of mental illness,and the issues of drug efficacy and safety due to individual differences cannot be ignored.Genetic factors,especially the genetic poly-morphisms related to drug-metabolizing enzymes,drug action targets,and risk,have a significant impact on drug responses.Pharmacogenomics,by detecting genetic polymorphisms,can reveal a patient's inherited tend-encies towards drug efficacy,pharmacokinetic characteristics,and potential toxicity,thereby predicting the therapeutic effects and adverse reactions of drug treatment,and providing guidance for personalized therapy.Therefore,individualized medication based on pharmacogenomics helps to improve cure rates,reduce relapse rates,and decrease medical costs,which is of great significance to clinical medication in mental illness.
