Serum levels and significance of S100β and IGF-1R in vascular cognitive impairment no dementia patients
10.3969/j.issn.1673-4130.2025.03.008
- VernacularTitle:非痴呆型血管性认知障碍患者血清S100β、IGF-1R水平及意义
- Author:
Shanshan LIU
1
;
Liping WANG
;
Juan CHAI
Author Information
1. 华中科技大学同济医学院附属梨园医院神经内科,湖北武汉 430000
- Keywords:
vascular cognitive impairment no dementia;
S100 calcium-binding protein β;
insulin-like growth factor 1 receptor
- From:
International Journal of Laboratory Medicine
2025;46(3):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels and significance of S100 calcium-binding protein β(S100β)and insulin-like growth factor 1 receptor(IGF-1R)in vascular cognitive impairment no dementia(VCIND)patients.Methods A total of fifty patients with VCIND due to cerebral infarction admitted to a hospital from June 2022 to June 2023 were selected as the VCIND group,50 cerebral infarction patients with no cognitive impairment(NCI)were selected as the NCI group,and 50 patients with no history of cerebrovas-cular disease admitted to a hospital during the same period were selected as the control group.Serum levels of S100β and IGF-1R were detected by enzyme-linked immunosorbent assay.Logistic regression analysis was used to evaluate whether serum S100β and IGF-1R levels were influential factors in the diagnosis of VCIND,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum S100β and IGF-1R level in VCIND.Results There were significant differences in proportion of hypertension and Hcy level among VCIND group,NCI group and control group(P<0.05).The serum S100β level in VCIND group was higher than that in NCI group and control group,and the difference was statistically significant(P<0.05).The serum IGF-1R level in VCIND group was lower than that in NCI group and control group,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that serum S100β≥1.26 μg/L and IGF-1R≤1.52 ng/mL were independent risk factors for VCIND(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum S100β level for VCIND di-agnosis was 0.734(95%CI:0.553-0.769),sensitivity was 75.8%,specificity was 67.3%,the AUC of serum IGF-1R level for diagnosis of VCIND was 0.806(95%CI:0.738-0.932),sensitivity was 69.5%,specificity was 72.2%.The diagnostic value of serum S100β and IGF-1R combined detection for VCIND was higher than that of single detection.Conclusion Serum S100β level increased and IGF-1R level decreased in patients with VCIND.The combined detection of serum S100β and IGF-1R has high diagnostic value for VCIND,and has the value of promotion and application in clinical practice.
