Predictive value of serum Perilipin 5 and growth hormone releasing peptide levels in the occurrence of major adverse cardiovascular events in patients with acute myocardial infarction
10.3969/j.issn.1673-4130.2025.03.007
- VernacularTitle:急性心肌梗死患者血清Perilipin 5、生长激素释放肽水平对MACE发生的预测价值
- Author:
Fenli ZHANG
1
;
Jing WANG
Author Information
1. 西安交通大学第一附属医院结构性心脏病科,陕西西安 710061
- Keywords:
acute myocardial infarction;
Perilipin 5;
growth hormone-releasing peptide;
major ad-verse cardiovascular events
- From:
International Journal of Laboratory Medicine
2025;46(3):287-291,296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum Perilipin 5 and growth hormone-releasing peptide(Ghrelin)levels in the occurrence of major adverse cardiovascular events(MACE)in patients with a-cute myocardial infarction(AMI).Methods A total of 148 patients with AMI treated in the First Affiliated Hospital of Xi'an Jiaotong University from February 2020 to July 2023 were selected as AMI group.Accord-ing to the occurrence of MACE,the patients were divided into the occurrence group(46 cases)and the non-oc-currence group(102 cases).Another 148 healthy subjects who underwent physical examination in the same period were selected as the control group.Serum Perilipin 5 and Ghrelin levels were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression analysis was conducted to analyze the influencing fac-tors of MACE occurrence in AMI patients,and the predictive value of serum Perilipin 5 and Ghrelin on MACE occurrence in AMI patients was analyzed by drawing receiver operating characteristic(ROC)curve.Results The serum levels of Perilipin 5 and Ghrelin in AMI group were significantly lower than those in con-trol group,and the difference was statistically significant(P<0.05).The proportion of cardiac function gradeⅢ to Ⅳ,the level of hypersensitive C-reactive protein and the proportion of coronary artery involved in the disease in the occurrence group were significantly higher than those in the non-occurrence group,while the se-rum levels of Perilipin 5,Ghrelin and left ventricular ejection fraction were significantly lower than those in the non-occurrence group,and the difference was statistically significant(P<0.05).Multivariate Logistic re-gression analysis showed that grade Ⅲ to Ⅳ and coronary artery involvement were the risk factors for MACE in AMI patients(P<0.05),and Perilipin 5 and Ghrelin were the protective factors for MACE in AMI patients(P<0.05).ROC curve analysis results showed that the area under the curve predicted by serum Perilipin 5 and Ghrelin combined was 0.915,which was better than that predicted by serum Perilipin 5 and Ghrelin a-lone.Conclusion Serum Perilipin 5 and Ghrelin levels have high predictive value for MACE occurrence in AMI patients.
