Expression of VEGFR3 and APPL1 in NSCLC tissues and adjacent tissues and their relationship with clinical pathology
10.3969/j.issn.1673-4130.2025.03.003
- VernacularTitle:VEGFR3及APPL1在NSCLC组织及癌旁组织中的表达及与临床病理的关系分析
- Author:
Chao SONG
1
;
Danna WANG
;
Lan YU
;
Kangwu WANG
;
Bo ZHU
Author Information
1. 蚌埠医科大学第一附属医院:胸外科,安徽蚌埠 233000
- Keywords:
non-small cell lung cancer;
adjacent tissues;
vascular endothelial growth factor receptor-3;
adaptor protein containing PH domain,PTB domain,and leucine zipper motif 1
- From:
International Journal of Laboratory Medicine
2025;46(3):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of vascular endothelial growth factor receptor-3(VEGFR3)and adaptor protein containing PH domain,PTB domain,and leucine zipper motif 1(APPL1)in non-small cell lung cancer(NSCLC)and their relationship with clinical pathology.Methods A total of 100 patients with NSCLC admitted to the First Affiliated Hospital of Bengbu Medical University from January 2019 to December 2020 were selected as the study objects,and the NSCLC tissues and adjacent tissues of the patients were collected.The expression of VEGFR3 and APPL1 was detected by immunohistochemistry,and the relationship between VEGFR3 and APPL1 expression and clinical pathology of patients was analyzed,as well as the predictive value of VEGFR3 and APPL1 for prognosis of patients with NSCLC.Results The posi-tive rates of VEGFR3 and APPL1 in NSCLC tissues and adjacent tissues were significantly different(P<0.05).The positive rate of VEGFR3 was significantly different in patients with different histological type,lymph node metastasis and tumor invasion(P<0.05).The positive rate of APPL1 was significantly different in patients with different histological type and tumor invasion(P<0.05).Spearman correlation analysis showed that VEGFR3 was positively correlated with APPL1 expression(r=0.330,P<0.05).The relative expression levels of VEGFR3 and APPL1 in death group were higher than those in survival group,and the difference was statistically significant(P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve of relative expression levels of VEGFR3 and APPL1 to predict the prognosis of NSCLC patients was 0.843(95%CI:0.757-0.908)and 0.799(95%CI:0.707-0.872).Conclusion The ex-pression of VEGFR3 and APPL1 in NSCLC patients is related to their clinical pathological features.The relative ex-pression levels of VEGFR3 and APPL1 are of great value in predicting the prognosis of NSCLC patients.
