Effect of USP44 and NCOR1 expression on prognosis in non-small cell lung cancer
10.3969/j.issn.1673-4130.2025.03.002
- VernacularTitle:非小细胞肺癌组织USP44、NCOR1表达对预后的影响
- Author:
Yunguo LIAO
1
;
Ziyu TANG
;
Dan DENG
;
Jingjing GUO
;
Shixiang QIU
;
Chao LI
;
Zhipeng FENG
Author Information
1. 首都医科大学附属北京安贞医院南充医院·南充市中心医院:介入医学科,四川南充 637000
- Keywords:
non-small cell lung cancer;
ubiquitin-specific peptidase 44;
nuclear receptor co-inhibitor 1;
prog-nosis
- From:
International Journal of Laboratory Medicine
2025;46(3):261-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ubiquitin-specific peptidase(USP)44 and nuclear receptor co-inhibitor 1(NCOR1)expression on prognosis in non-small cell lung cancer.Methods A total of 98 pa-tients with non-small cell lung cancer admitted to a hospital from May 2019 to May 2021 were selected as the study objects,and non-small cell lung cancer tissues and adjacent tissues were collected to detect the expres-sion levels of USP44 and NCOR1 in these tissues by immunohistochemical staining.The relationship between USP44 and NCOR1 expression and pathological features of non-small cell lung cancer patients was analyzed,and the prognostic factors of non-small cell lung cancer patients were analyzed by multivariate Cox regression.Results The positive expression rates of USP44 and NCOR1 in non-small cell lung cancer tissues were higher than those in adjacent tissues,the difference was statistically significant(P<0.05).The positive expression rates of USP44 and NCOR1 in patients with medium-low differentiation,lymph node metastasis,clinical stageⅢ to Ⅳ,and pleural metastasis were higher than those in patients with highly differentiated,no lymph node metastasis,clinical stage Ⅰ to Ⅱ,and no pleural metastasis,and the difference was statistically significant(P<0.05).The 3-year overall survival rate of USP44 and NCOR1 negative non-small cell lung cancer patients was higher than that of USP44 and NCOR1 positive non-small cell lung cancer patients,and the difference was statistically significant(all P<0.05).Multivariate Cox regression analysis showed that pleural metastasis,USP44 positive and NCOR1 positive were prognostic factors in non-small cell lung cancer patients(P<0.05).Conclusion The expression of USP44 and NCOR1 in patients with non-small cell lung cancer can be used as biomarkers for prognosis assessment,and provide evidence for progression assessment and clinical de-cision making of non-small cell lung cancer.
