Predictive value of serum MMP-2,T-AOC,and CRP for postoperative total extraperitoneal repair recurrence in patients with inguinal hernia
10.3969/j.issn.1673-4130.2025.02.014
- VernacularTitle:血清MMP-2、T-AOC、CRP对腹股沟疝患者TEP术后复发的预测价值
- Author:
Limin WEI
1
;
Yunge WANG
;
Guanghui WANG
;
Haige LEI
Author Information
1. 西安交通大学第一附属医院普通外科,陕西西安 710061
- Keywords:
inguinal hernia;
matrix metalloproteinase-2;
total antioxidant capacity;
C-reactive pro-tein;
laparoscopic total extraperitoneal repair surgery;
recurrence
- From:
International Journal of Laboratory Medicine
2025;46(2):201-204,209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum metalloproteinase-2(MMP-2),total antioxi-dant capacity(T-AOC),C-reactive protein(CRP),and recurrence in inguinal hernia(IH)patients with postoperative laparoscopic total extraperitoneal repair(TEP),as well as their predictive value.Methods A total of 122 IH pa-tients undergoing TEP in the First Affiliated Hospital of Xi'an Jiaotong University from January 2019 to De-cember 2022 were selected as the observation group,and 122 healthy subjects during the same period were se-lected as the control group.The patients were followed up for 10 months,and were divided into relapse group(n=37)and recovery group(n=85)according to their recurrence situation.Serum MMP-2 levels were detec-ted by automatic biochemical analyzer,T-AOC levels were determined by chemical colorimetric method,and CRP levels were assessed by enzyme-linked immunosorbent assay.The influencing factors of TEP recurrence in IH patients were analyzed by Logistic regression.The predictive value of serum MMP-2,T-AOC and CRP for postoperative TEP recurrence in IH patients was analyzed by receiver operating characteristic(ROC)curve.Results Serum MMP-2 and CRP levels in observation group were significantly higher than those in control group(P＜0.05),and T-AOC levels were significantly lower than those in control group(P＜0.05).MMP-2 and CRP in relapse group were significantly higher than those in recovery group(P＜0.05),and T-AOC level was lower than that in recovery group(P＜0.05).The area under the curve(AUC)of serum MMP2,T-AOC and CRP in pre-dicting TEP recurrence in IH patients were 0.775,0.804 and 0.731,respectively,and the AUC of the combined pre-diction of the three was 0.887,which was better than that of each indicator alone(Z=2.597,1.983,3.275,P=0.009,0.047,0.001).Conclusion Serum levels of MMP-2,T-AOC and CRP in IH patients with postoperative TEP recurrence significantly increase,which can be used as effective indicators to predict the postoperative TEP recurrence in IH patients,and the combined prediction efficiency of the three is higher.
