Relationship between Lp-PLA2,HGI and severity of type 2 diabetic retinopathy
10.3969/j.issn.1673-4130.2025.02.003
- VernacularTitle:Lp-PLA2、HGI与2型糖尿病视网膜病变严重程度的关系研究
- Author:
Shaolin PENG
1
;
Shuibing YANG
;
Jingjin YANG
;
Xiaoyu LU
;
Meibiao ZHANG
Author Information
1. 湖南医药学院总医院/吉首大学附属第四医院内分泌代谢科/国家代谢性疾病临床医学研究中心怀化分中心/国家标准化代谢性疾病管理中心(MMC)怀化分中心,湖南怀化 418000
- Keywords:
diabetic retinopathy;
lipoprotein-associated phospholipase A2;
hemoglobin glycation index
- From:
International Journal of Laboratory Medicine
2025;46(2):141-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between lipoprotein-associated phospholipase A2(Lp-PLA2),hemoglobin glycotion index(HGI)and the severity of type 2 diabetic retinopathy.Methods A total of 120 patients with type 2 diabetes mellitus who were hospitalized in the General Hospital of Hunan Medical University from January 2021 to June 2022 were selected and divided into type 2 diabetes without retinopathy group(NDR group,n=45),non-proliferative diabetic retinopathy group(NPDR group,n=45)and prolifera-tive diabetic retinopathy group(PDR group,n=30).In the same period,50 healthy subjects were randomly selected as control group.The clinical data,Lp-PLA2 and HGI levels of each group were collected and com-pared,and the correlation between different HGI and Lp-PLA2 levels and the severity of the disease was ana-lyzed.Results The levels of Lp-PLA2 and HGI in NDR,NPDR and PDR groups were higher than those in control group(P＜0.05).The proportion of patients with NPDR and PDR in high-Lp-PLA group(H-Lp-PLA2 group)and high-HGI group(H-HGI group)were higher than those in low-HGI group(L-HGI group)and low-Lp-PLA2 group(L-Lp-PLA2 group),and the differences were statistically significant(P＜0.05).Multiple Logistic regression analysis showed that Lp-PLA2 and HGI were risk factors for DR(P＜0.05),and were positively correlated with the severity of type 2 diabetic retinopathy(P＜0.05).Conclusion HGI and Lp-PLA2 are closely related to the severity of retinopathy in type 2 diabetes mellitus,and may be used as new indicators to predict the severity of the disease.
