Research progress of sulfotransferases SULTs in regulating glucose and lipid metabolism
10.3969/j.issn.1673-4130.2025.01.021
- VernacularTitle:磺基转移酶SULTs调节糖脂代谢的研究进展
- Author:
Yali REN
1
;
Xiaopeng CHEN
;
Xiao ZHANG
;
Song ZHANG
Author Information
1. 武汉科技大学医学部医学院,湖北武汉 430065
- Keywords:
sulfotransferase;
sulfation;
glucose metabolism;
lipid metabolism;
metabolic disease
- From:
International Journal of Laboratory Medicine
2025;46(1):102-106,112
- CountryChina
- Language:Chinese
-
Abstract:
The biotransformation processes in the human body play a crucial role in maintaining the inter-nal environment's stability by converting exogenous compounds and endogenous metabolites into substances with increased polarity or water solubility.This alteration in toxicity or pharmacological effects facilitates their excretion from the body.Sulfation,an important type of phase Ⅱ biotransformation reaction,is primarily me-diated by members of the cytosolic sulfotransferases(also known as sulfotransferases,SULTs)superfamily.Recent studies have uncovered the significant roles of SULTs in drug metabolism,tumorigenesis,inflammato-ry responses,hormone regulation,and energy metabolism.This article provides a comprehensive review of the regulatory roles and molecular mechanisms of the SULTs superfamily members in carbohydrate and lipid me-tabolism,aiming to offer new insights into the mechanism research and drug development for disorders related to carbohydrate and lipid metabolism dysregulation.
