Construction and evaluation of a prognostic column chart model for radical resection of pancreatic head cancer based on preoperative SIRI,HELPP,and CONUT
10.3969/j.issn.1673-4130.2025.01.020
- VernacularTitle:基于术前SIRI、HELPP评分及CONUT评分的胰头癌根治术预后列线图模型构建
- Author:
Jian SONG
1
;
Hui SHI
;
Fan YANG
;
Wanxiang WANG
Author Information
1. 内蒙古自治区人民医院急诊重症医学科,内蒙古呼和浩特 010000
- Keywords:
pancreatic head cancer;
systemic inflammatory response index;
Heidelberg prognostic pan-creatic cancer score;
controlling nutritional status score;
Nomogram;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(1):96-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between systemic inflammatory response index(SIRI),Heidelberg pancreatic cancer prognosis(HELPP)score,controlled nutritional status(CONUT)score and the related clinicopathological characteristics and survival prognosis of patients after radical resection of pancreatic head cancer,and to build a survival prediction model and evaluate its efficacy.Methods A retrospective analy-sis was conducted on the clinical and pathological data of 169 patients diagnosed with pancreatic head cancer and undergoing radical pancreaticoduodenectomy at the Department of Hepatobiliary Pancreatic Spleen Sur-gery in Inner Mongolia Medical University Affiliated Hospital from January 1,2011 to June 30,2021.Multiva-riate COX regression analysis was used to conduct a proportional hazards model for univariate and multivariate analysis of prognostic factors affecting the overall survival of patients with pancreatic head cancer after surger-y.A prognostic column chart was constructed using R4.2.2.Results The median survival time of 169 pa-tients was 20.8 months,and the cumulative survival rates at 1,2,and 3 years after surgery were 71.6％,38.5％,and 15.4％,respectively.Patients with SIRI ≥1.74,HELPP score＞3,and CONUT score ≥3 had worse prognosis.Multivariate COX regression analysis revealed that TNM staging,tumor maximum diame-ter,carbohydrate antigen(CA)19-9,SIRI,HELPP score,and CONUT score were all independent risk factors affecting prognosis(P＜0.05).The prognostic column chart constructed based on this had good predictive performance.Conclusion SIRI,HELPP score and CONUT score are potential indicators for predicting the prognosis of patients after radical resection of pancreatic head cancer.TNM staging,maximum tumor diame-ter,CA19-9,SIRI,HELPP score,and CONUT score are independent risk factors affecting the prognosis of pancreatic head cancer.The established nomogram model can predict the long-term survival of patients with pancreatic head cancer.
