Research progress on the role of remnant lipoprotein and inflammation in atherosclerotic cardiovascular disease
10.3969/j.issn.1673-4130.2024.24.019
- VernacularTitle:脂蛋白残粒胆固醇和炎症在动脉粥样硬化性心血管疾病中的作用研究进展
- Author:
Die YU
1
;
Jihua ZHOU
;
Shuangshuang CHEN
;
Zhanke WANG
Author Information
1. 宁波美康盛德医学检验所,浙江宁波 315105
- Keywords:
remnant lipoprotein cholesterol;
inflammation;
atherosclerosis
- From:
International Journal of Laboratory Medicine
2024;45(24):3039-3044
- CountryChina
- Language:Chinese
-
Abstract:
Remnant lipoprotein cholesterol(RLP-C)are composed of very low-density lipoprotein 3 cho-lesterol(VLDL3-C)and intermediate density lipoprotein cholesterol(IDL-C),which are the remnants produced by the hydrolysis of triglyceride-rich lipoproteins(TRLs).RLP-C levels are significantly related to the occur-rence of atherosclerotic cardiovascular disease(ASCVD)and are the remaining risk factors for ASCVD other than low-density lipoprotein cholesterol(LDL-C).Subintimal accumulation of atherogenic lipoprotein particles causes chronic inflammatory responses,including innate immune responses and adaptive immune responses.Unlike LDL-C,RLP-C is more likely to remain under the arterial endothelium and is directly phagocytosed by macrophages without oxidative modification,leading to the formation of foam cells and inflammatory reaction in the arterial wall endothelium,thereby forming atherosclerotic plaques.This review summarizes the concept of RLP-C,the relationship and quantitative detection method of RLP-C and ASCVD,and the mechanism of in-flammatory in ASCVD caused by RLP-C.
