Diagnostic value of serum Irisin,FGF-23 and N-MID in elderly patients with type 2 diabetes with osteoporosis
10.3969/j.issn.1673-4130.2024.24.016
- VernacularTitle:血清Irisin、FGF-23、N-MID联合检测对老年2型糖尿病患者骨质疏松的诊断价值
- Author:
Wenli LEI
1
;
Yani WANG
;
Lidong LIU
;
Lihong ZHANG
;
Yanning CAO
;
Jie LI
Author Information
1. 空军军医大学空军第九八六医院内分泌科,陕西西安 710054
- Keywords:
Irisin;
fibroblast growth factor 23;
N-mid osteocalcin;
type 2 diabetes mellitus;
osteo-porosis
- From:
International Journal of Laboratory Medicine
2024;45(24):3026-3029,3034
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of serum Irisin,fibroblast growth factor 23(FGF23)and N-mid osteocalcin(N-MID)in the elderly patients with type 2 diabetes mellitus(T2DM)with osteoporo-sis(OP).Methods A total of 120 patients with T2DM combined with OP who were treated in the hospital from January 2021 to June 2023 were selected as the T2DM+OP group,and 120 patients with pure T2DM who were treated in the hospital during the same period were selected as the T2DM group.The levels of serum Irisin,FGF-23 and N-MID were compared between two groups.Multivariate Logistic regression was applied to analyze the influencing factors of OP in T2DM patients.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum Irisin,FGF-23 and N-MID levels for the occurrence of OP in T2DM patients.Results FGF-23,N-MID,fasting plasma glucose(FPG),fasting insulin(FINS),high-density lipoprotein cholesterol(HDL-C)in T2DM+OP group were obviously higher than those in T2DM group(P＜0.05),course of diabetes was longer than that in T2DM group(P＜0.05),and bone mineral density and ser-um Irisin level were lower than those in T2DM group(P＜0.05).Multivariate Logistic regression analysis showed that FGF-23,N-MID,diabetes course,FPG and FINS were independent risk factors for OP in T2DM patients(P＜0.05),while Irisin and bone mineral density were protective factors for OP in T2DM patients(P＜0.05).The area under the curve(AUC)of the combined diagnosis of serum Irisin,FGF-23 and N-MID in T2DM patients with OP was 0.886,with sensitivity of 90.00％and specificity of 74.17％.The AUC of the combination of the three for diagnosing OP in T2DM patients was larger than that of serum Irisin,FGF-23 and N-MID alone(Zcombination-Irisin=3.945,Zcombination-FGF23=5.119,Zcombination-N-MID=3.778,all P＜0.001).Conclusion The serum levels of FGF-23 and N-MID in patients with T2DM combined with OP increase,while the level of Iri-sin decreases.The combination of the three has high diagnostic value for the occurrence of OP in elderly T2DM patients.
