Application value of serum GDF-15 combined IL-33 in the diagnosis and prognosis of elderly pulmonary infection patients in ICU
10.3969/j.issn.1673-4130.2024.24.015
- VernacularTitle:血清GDF-15、IL-33联合检测在ICU老年肺部感染患者诊断及预后中的应用价值
- Author:
Cuiying YANG
1
;
Zheng ZHAO
;
Liangliang ZHANG
;
Zhuo LIU
;
Zhao JIN
Author Information
1. 河北省邯郸市中心医院西区胸外一科,河北邯郸 056000
- Keywords:
intensive care unit;
pulmonary infection;
growth differentiation factor 15;
interleukin-33;
diagnosis;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(24):3021-3025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of serum growth differentiation factor 15(GDF-15)combined interleukin-33(IL-33)in the diagnosis and prognosis of elderly pulmonary infection patients in in-tensive care unit(ICU).Methods A total of 73 elderly patients with pulmonary infection admitted to the ICU in the hospital from February 2021 to February 2023 were collected as study group.Based on the prognosis of the patients after 30 days of treatment,study group was separated into a survival group(52 cases)and a death group(21 cases).Another 70 elderly patients who were admitted to the ICU in the hospital but did not have pulmonary infection were taken as control group.All clinical data of the study subjects were collected for com-parative analysis.Enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of GDF-15 and IL-33 in the serum of all study subjects.Multivariate Logistic regression was applied to analyze the factors affecting the prognosis of elderly patients with pulmonary infection in ICU.Receiver operating characteristic(ROC)curve was applied to analyze the value of serum GDF-15 and IL-33 levels in the diagnosis and progno-sis evaluation of elderly pulmonary infection patients in ICU.Results Compared with control group,the ser-um levels of GDF-15 and IL-33 in study group were obviously higher(P＜0.05).Serum levels of GDF-15 and IL-33 were independent risk factors for lung infection in elderly ICU patients(P＜0.05).The area under the curve(AUC)of serum GDF-15 and IL-33 levels for diagnosing pulmonary infection in elderly ICU patients was 0.912,0.896,and 0.951,respectively,and the AUC of the combined detection of the two was larger than that of GDF-15 and IL-33 alone(Zcombined diagnosis-GDF 15=2.630,Zcombined diagnosis-IL-33=2.432,P=0.009,0.015).There were no statistically significant differences in age,gender,body mass index,platelet count,serum creatinine,hemoglobin,and urea nitrogen between the survival group and the death group(P＞0.05).The white blood cell count,neutrophil count,and serum levels of GDF-15 and IL-33 in the death group were higher than those in the survival group(P＜0.05),while lymphocyte count was lower than that in the survival group(P＜0.05).The results of multivariate Logistic regression analysis showed that neutrophil count,white blood cell count,serum GDF-15,IL-33 levels were independent risk factors for death in elderly lung infection patients in ICU(P＜0.05),while lymphocyte count was an independent protective factor for death in elderly lung infec-tion patients in ICU(P＜0.05).The area under the curve(AUC)of serum GDF-15 and IL-33 alone and in combination in predicting the prognosis of elderly patients with pulmonary infection in ICU was 0.870,0.836,and 0.960,respectively,and the AUC of the combined diagnosis of the two was larger than that of the single prediction of GDF-15 and IL-33(Zcombination-GDF-15=2.521,Zcombination-IL-33=2.946,P=0.012,0.003).Conclusion The levels of serum GDF-15 and IL-33 are increased in elderly patients with pulmonary infection in ICU,which has certain value in the diagnosis and prognosis of the patients,and the combination of the two has better diagnostic and prognostic efficacy.
