Relationship between serum SLC7A11 and GPX4 levels and chemotherapy sensitivity and prognosis in prostate cancer patients
10.3969/j.issn.1673-4130.2024.24.011
- VernacularTitle:前列腺癌患者血清SLC7A11和GPX4水平与化疗敏感性及预后的关系
- Author:
Yazhen LI
1
;
Cancan DING
;
Haidong WANG
;
Xuejiao GUO
;
Wenyan LIU
Author Information
1. 邯郸市第一医院泌尿二科,河北邯郸 056000
- Keywords:
prostate cancer;
solute carrier family 7 member 11;
glutathione peroxidase 4;
chemo-therapy sensitivity;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(24):2999-3003
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between serum solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4)levels and chemotherapy sensitivity and prognosis in pros-tate cancer patients.Methods A total of 106 prostate cancer patients admitted to the hospital from January 2019 to December 2022 were selected as the prostate cancer group,106 healthy males who came to the hospital for physical examination were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of SLC7A11 and GPX4 in serum.The prognostic factors of prostate cancer pa-tients were analyzed by multivariate Logistic regression.The predictive value of SLC7A11 and GPX4 levels in serum for the prognosis of prostate cancer patients were analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the serum levels of SLC7A11 and GPX4 in the prostate cancer group were obviously increased(P＜0.05).Compared with before chemotherapy,the serum levels of SLC7A11 and GPX4 in the prostate cancer patients after chemotherapy were obviously reduced(P＜0.05).The serum level of SLC7A11 in the prostate cancer patients with different tumor maximum diameter,Gleason score,clinical pathological stage,lymph node metastasis,tumor differentiation degree,and prostate-specific an-tigen(PSA)level were statistically significant(P＜0.05).The serum level of GPX4 in the prostate cancer pa-tients with different tumor differentiation degrees,Gleason scores,clinical pathological stages,lymph node me-tastasis,and PSA level were statistically significant(P＜0.05).The serum levels of SLC7A11 and GPX4 in the poor prognosis group were obviously higher than those in the good prognosis group(P＜0.05).Multivariate Logistic regression analysis results showed that the levels of SLC7A11 and GPX4 were influencing factors for the prognosis of prostate cancer(P＜0.05).The results of ROC curve analysis showed that the combination of SLC7A11 and GPX4 levels in serum had a better prognostic value than single index(P＜0.05).Conclusion The levels of SLC7A11 and GPX4 in the serum of prostate cancer patients are obviously in-creased,which is closely related to chemotherapy sensitivity and could be used as biomarkers for predicting the prognosis of prostate cancer patients.
