Relationship between peripheral blood NLR and CAR and early postoperative anastomotic leakage in esophageal cancer patients
10.3969/j.issn.1673-4130.2024.24.010
- VernacularTitle:食管癌患者外周血NLR、CAR与术后早期吻合口瘘的关系研究
- Author:
Lin LIU
1
;
Chunyong SU
;
Huanfang FAN
Author Information
1. 邯郸市中心医院胸外一科,河北邯郸 056001
- Keywords:
esophageal cancer;
esophagectomy;
neutrophil/lymphocyte ratio;
C-reactive protein/al-bumin ratio;
early anastomotic leakage
- From:
International Journal of Laboratory Medicine
2024;45(24):2995-2998
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between peripheral blood neutrophil/lymphocyte ratio(NLR),C-reactive protein/albumin ratio(CAR)and early postoperative anastomotic leakage in patients with esophageal cancer.Methods A total of 116 esophageal cancer patients who were treated in Handan Central Hospital and underwent esophagectomy from December 2016 to January 2024 were retrospectively included as research objects,and the patients were divided into AL group(21 cases)and non-AL group(95 cases)based on whether AL occurred within 7 days after surgery.General information of patients was collected,peripheral blood neutrophil,lymphocyte,C-reactive protein,and albumin levels of all patients were measured,and NLR and CAR were calculated.Multivariate Logistic regression was used to analyze the factors affecting early post-operative AL in patients with esophageal cancer.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of NLR,CAR and their combination for early postoperative AL in patients with esophageal cancer.Results The peripheral blood NLR and CAR in the AL group were higher than those in the non-AL group,and the operation time was shorter than that in the non-AL group(P＜0.05).Multivariate Logistic regression analysis results showed that NLR and CAR were risk factors for early postoperative AL in esophageal cancer patients(P＜0.05).The ROC curve results showed that the area under the curve(AUC)of NLR,CAR and combined prediction of early postoperative AL in patients were 0.875,0.871,and 0.958,and the AUC of combined prediction was greater than that of individual prediction(Z=2.274,2.927,P＜0.05).Conclusion Peripheral blood NLR and CAR in patients with esophageal cancer are closely related to early postoperative AL.
