Relationship between serum SDF-1 and CXCR4 levels and disease outcome in children with acute upper respiratory tract infection
10.3969/j.issn.1673-4130.2024.24.006
- VernacularTitle:急性上呼吸道感染患儿血清SDF-1、CXCR4水平与疾病转归的关系
- Author:
Weidong TANG
1
;
Yu WANG
;
Xiangzhen LU
;
Li LI
;
Ping XIONG
Author Information
1. 泸州市妇幼保健院(泸州市第二人民医院)检验科,四川泸州 646000
- Keywords:
acute upper respiratory tract infection;
stromal cell derived factor-1;
chemokine receptor 4;
disease outcome
- From:
International Journal of Laboratory Medicine
2024;45(24):2973-2976,2982
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the levels of serum stromal cell derived factor-1(SDF-1),chemokine receptor 4(CXCR4)and disease outcome in children with acute upper respiratory tract infection.Methods A total of 115 children with acute upper respiratory tract infection admitted to Luzhou Maternal and Child Health Hospital from February 2021 to February 2023 were selected as the study group,and according to the disease outcome,they were divided into good group(77 cases)and poor group(38 ca-ses).Another 105 healthy children who underwent physical examination in Luzhou Maternal and Child Health Hospital were selected as the control group.Serum levels of SDF-1 and CXCR4 in all research objects were de-tected.Receiver operating characteristic(ROC)curve was used to evaluate the value of serum SDF-1 and CX-CR4 in assessing the disease outcome of children with acute upper respiratory tract infection.Multivariate Lo-gistic stepwise regression analysis was conducted to identify the relevant factors affecting the disease outcome of children with acute upper respiratory tract infection.Results Serum levels of SDF-1 and CXCR4 in the study group were higher than those in control group(P＜0.05).The levels of serum SDF-1 and CXCR4 in the good group were lower than those in the poor group(P＜0.05).ROC curve results showed that the area un-der the curve(AUC)of serum SDF-1 and CXCR4 to evaluate the disease outcome of children with acute upper respiratory tract infection were 0.854(95％CI:0.804-0.904)and 0.867(95％CI:0.817-0.917).The AUC of serum SDF-1 combined with CXCR4 to evaluate the disease outcome of children with acute upper respirato-ry tract infection was 0.924(95％CI:0.874-0.974).The results of multivariate Logistic stepwise regression analysis showed that serum interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),tumor necro-sis factor-α(TNF-α),SDF-1,and CXCR4 were all factors affecting the disease outcome of children with acute upper respiratory tract infections(P＜0.05).Conclusion Serum levels of SDF-1 and CXCR4 are increased in children with acute upper respiratory tract infection,and their changes are closely related to the disease out-come.The combination of the two has important diagnostic value for the disease outcome of children with a-cute upper respiratory tract infections.
