Value of serum HMGB1 and VEGFA levels in diagnosing the diabetic retinopathy and predicting the prognosis of patients
10.3969/j.issn.1673-4130.2024.24.005
- VernacularTitle:血清HMGB1、VEGFA水平诊断糖尿病视网膜病变及预测患者预后的价值
- Author:
Jing WEI
1
;
Jincheng ZHANG
;
Yanan SHI
;
Huiqin ZHANG
;
Yan WU
Author Information
1. 沧州市中心医院内分泌一科,河北沧州 061000
- Keywords:
diabetic retinopathy;
high mobility group b1;
vascular endothelial growth factor A
- From:
International Journal of Laboratory Medicine
2024;45(24):2967-2972
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum high mobility group B1(HMGB1)and vascular endothelial growth factor A(VEGFA)levels in diagnosing the diabetic retinopathy(DR)and predicting the prognosis of patients.Methods A total of 202 patients with type 2 diabetes mellitus(T2DM)admitted to the hospital from January 2021 to January 2022 were selected and divided into DR group(143 cases)and T2DM group(59 cases)based on whether DR occurred or not.According to the degree of lesions,DR groups were di-vided into proliferative DR(PDR)group(76 cases)and non PDR(NPDR)group(67 cases).The DR group was followed up for 1 year,and was divided into poor prognosis group(43 cases)and good prognosis group(143 cases)according to the occurrence of visual disability.46 healthy volunteers who underwent the physical examination during the same period were selected as the control group.Serum HMGB1 and VEGFA levels were measured by enzyme-linked immunosorbent assay.Pearson correlation was used to analyze the correla-tion between serum HMGB1 and VEGFA levels in patients with DR.Multivariate Logistic regression was used to analyze the factors affecting the occurrence of DR and the prognosis of patients with DR,and receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum HMGB1 and VEGFA levels for DR and the predictive value for poor prognosis in patients with DR.Results Serum HMGB1 and VEGFA levels increased sequentially in the control group,the T2DM group,the NPDR group,and the PDR group(P＜0.05).Pearson correlation analysis showed that there was a positive correlation between serum HMGB1 and VEGFA levels in DR patients(r=0.730,P＜0.001).After 1-year follow-up,the incidence of poor prognosis in 143 DR patients was 30.07％(43/143).Multivariate Logistic regression analysis showed that prolonged duration of T2DM,elevated glycosylated hemoglobin(HbA1c)level,elevated HMGB1 level,and elevated VEGFA level were independent risk factors affecting the occurrence of DR and poor prognosis of patients with DR(P＜0.05).ROC curve analysis showed that the area under the curve of the combined detec-tion of serum HMGB1 and VEGFA levels for diagnosing DR and predicting poor prognosis in patients with DR were 0.871 and 0.867,respectively,which were larger than 0.784,0.800 and 0.772,0.780 of the diagnosis and prediction of serum HMGB1 and VEGFA levels alone(P＜0.05).Conclusion Elevated serum HMGB1 and VEGFA levels in DR patients are closely associated with the occurrence of DR and poor prognosis in DR patients,and the combination of serum HMGB1 and VEGFA levels has high value for the diagnosis of DR and the prediction of poor prognosis in DR patients.
