Relationship between serum sCD40L,ADAMTS13 and postoperative lower extremity deep vein thrombosis in elderly patients with hip fractures
10.3969/j.issn.1673-4130.2024.24.002
- VernacularTitle:血清sCD40L、ADAMTS13与老年髋部骨折患者术后下肢深静脉血栓形成的关系
- Author:
Guangyu FU
1
;
Changming ZHOU
;
Jianmin LIU
;
Yan LI
Author Information
1. 大连市第二人民医院骨科,辽宁大连 116013
- Keywords:
soluble cell surface differentiation antigen 40 ligand;
a disintegrin-like and metalloproteinase with thrombospondin type-1 motif 13;
hip fracture;
lower extremity deep vein thrombosis
- From:
International Journal of Laboratory Medicine
2024;45(24):2951-2955
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum soluble cell surface differentiation antigen 40 ligand(sCD40L),a disintegrin-like and metalloproteinase with thrombospondin type-1 motif 13(ADAMTS13)levels and postoperative lower extremity deep vein thrombosis(DVT)formation in elderly pa-tients with hip fractures.Methods A total of 192 elderly patients with hip fractures who visited the hospital from June 2022 to June 2023 were selected and separated into non DVT group(120 cases)and DVT group(72 cases)based on whether they experienced lower extremity DVT after surgery.Enzyme-linked immunosorbent assay was applied to detect serum sCD40L and ADAMTS13 levels in each group.Pearson method was applied to analyze the correlation between serum sCD40L and ADAMTS13 levels in patients.Multivariate Logistic re-gression model was applied to analyze the factors affecting postoperative lower extremity DVT in elderly pa-tients with hip fractures.Receiver operating characteristic(ROC)curve was applied to evaluate the predictive value of serum sCD40L and ADAMTS13 levels for postoperative lower extremity DVT in elderly patients with hip fractures.Results There were statistically significant differences in the proportion of hyperlipidemia and the time from fracture to surgery between the two groups(P＜0.05).Compared with the non DVT group,the serum sCD40L level in the DVT group increased(P＜0.05)and the ADAMTS13 level decreased(P＜0.05).Pearson method results showed that the serum sCD40L level was negatively correlated with ADAMTS13 level in patients(r=-0.457,P＜0.001).Multivariate Logistic regression model analysis showed that hyperlipi-demia,long time from fracture to surgery,increased level of serum sCD40L were risk factors for postoperative lower extremity DVT in elderly patients with hip fractures(P＜0.05),and the increased level of serum AD-AMTS13 was a protective factor for postoperative lower extremity DVT in patients with hip fractures(P＜0.05).The area under the curve of the combined prediction of serum sCD40L and ADAMTS13 for postopera-tive lower extremity DVT in elderly patients with hip fractures was 0.812,which was larger than that of sCD40L and ADAMTS13 alone(P＜0.05).Conclusion Serum sCD40L level increases and ADAMTS13 level decreases in elderly patients with hip fracture who had lower extremity DVT after surgery,the two could re-flect the risk of DVT and have predictive value for the occurrence of lower extremity DVT in elderly patients with hip fracture.
