Serum levels of Sestrin2 and Survivin in patients with acute myocardial infarction and their relationship with coronary artery disease
10.3969/j.issn.1673-4130.2024.23.019
- VernacularTitle:Sestrin2、Survivin在急性心肌梗死患者血清中水平及其与冠状动脉病变的关系
- Author:
Zhuoling JIANG
1
;
Miaomiao WANG
;
Shuting LU
Author Information
1. 陕西省汉中市三二○一医院,陕西汉中 723000
- Keywords:
myocardial infarction;
Sestrin2;
Survivin;
coronary artery disease
- From:
International Journal of Laboratory Medicine
2024;45(23):2913-2917
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of Sestrin2 and Survivin in patients with acute myo-cardial infarction(AMI)and their correlation with the degree of coronary artery stenosis.Methods A total of 120 AMI patients admitted to Hanzhong 3201 Hospital from October 2020 to December 2022 were selected as the observation subjects,and there were 67 cases of ST-segment elevation myocardial infarction(STEMI)and 53 cases of non-ST-segment elevation myocardial infarction(NSTEMI).According to the Gensini score,pa-tients were grouped into mild stenosis group and severe stenosis group,60 patients who underwent coronary angiography(stenosis degree＜50％)at the same time and did not meet the diagnosis standard of AMI were regarded as the control group.The levels of serum Sestrin2 and Survivin were detected by enzyme linked im-munosorbent assay,Spearman method was used for correlation analysis,and receiver operating characteristic curve was applied to analyze the diagnostic value of serum Sestrin2 and Survivin in severe stenotic AMI.Results There were statistically significant differences in brain natriuretic peptide,troponin,creatine kinase isoenzyme,left ventricular ejection fraction,fasting plasma glucose among the control group,NSTEMI group and STEMI group(P＜0.05).Compared with the control group,the levels of serum Sestrin2 and Survivin in NSTEMI group and STEMI group were obviously higher(P＜0.05).Serum Sestrin2 and Survivin levels in-creased with the increase of coronary artery lesion number and stenosis degree in AMI patients(P＜0.05).Serum Sestrin2 and Survivin levels were positively correlated with the number of coronary lesions,SYNTAX score and Gensini score in AMI patients(P＜0.05).The area under the curve(AUC)of serum Sestrin2 and Survivin in diagnosis of severe stenotic AMI alone and in combination were 0.840,0.823 and 0.920,respec-tively,and AUC of the combined detection was larger than those of singe detection(P＜0.05).Conclusion The serum levels of Sestrin2 and Survivin in patients with AMI are increased,they are related to the degree of coronary artery stenosis,and they may become marker to evaluate the degree of coronary artery disease.
