Serum FGF23 and SFRP4 levels and their diagnostic value in patients with diabetic retinopathy
10.3969/j.issn.1673-4130.2024.23.016
- VernacularTitle:糖尿病视网膜病变患者血清FGF23、SFRP4水平及其诊断价值
- Author:
Zhen ZHENG
1
;
Ningning YANG
;
Xueming FAN
Author Information
1. 安徽医科大学附属六安医院内分泌科,安徽六安 237000
- Keywords:
diabetic retinopathy;
fibroblast growth factor 23;
secreted frizzled-related protein 4;
di-agnosis
- From:
International Journal of Laboratory Medicine
2024;45(23):2899-2902,2907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of serum levels of fibroblast growth factor 23(FGF23)and secreted frizzled-related protein 4(SFRP4)in patients with diabetic retinopathy and their diagnostic value.Methods A total of 98 patients with diabetes who visited the hospital from July 2020 to May 2023 were re-garded as research objects.According to whether the patients had retinopathy,they were separated into reti-nopathy group(38 cases)and non retinopathy group(60 cases).Another 86 healthy individuals who under-went physical examination in the hospital were regarded as the health group.Enzyme linked immunosorbent assay was applied to detect serum levels of FGF23 and SFRP4 in each group,Pearson correlation analysis was used to analyze the correlation between serum FGF23 and SFRP4 levels in patients with diabetic retinopathy.The clinical data of the retinopathy group and the non retinopathy group were compared.Multivariate Logistic regression was used to analyze the related factors affecting diabetic retinopathy.Receiver operating character-istic curve was used to evaluate the diagnostic value of serum FGF23 and SFRP4 levels for diabetic retinopa-thy.Results The serum levels of FGF23 and SFRP4 increased sequentially in the health group,non retinopa-thy group,and retinopathy group(P＜0.05).Pearson correlation analysis showed that there was a positive correlation between serum FGF23 and SFRP4 levels in patients with diabetic retinopathy(r=0.463,P＜0.001).There were statistically significant differences in the diabetes course and percentage of hypertension between the non retinopathy group and the retinopathy group(P＜0.05).Hypertension,diabetes course,ser-um FGF23,SFRP4 levels were risk factors for retinopathy in diabetes patients(P＜0.05).The area under the curve of the combination of serum FGF23 and SFRP4 in the diagnosis of diabetic retinopathy was 0.965,the sensitivity was 89.47％,and the specificity was 95.00％,which were superior to the single diagnosis of FGF23 and SFRP4(Zcombination-FGF23=2.437,P=0.015,Zcombination-SFRP4=3.674,P＜0.001).Conclusion The levels of se-rum FGF23 and SFRP4 are elevated in patients with diabetic retinopathy.The combined detection of FGF23 and SFRP4 has high clinical diagnostic value for diabetic retinopathy.
