Expression of MDA5 in non-small cell lung cancer and prediction of the risk of developing interstitial lung disease
10.3969/j.issn.1673-4130.2024.23.015
- VernacularTitle:MDA5在非小细胞肺癌中的表达及其预测间质性肺疾病发生风险的研究
- Author:
Tao TAO
1
;
Xiaoli BAO
;
Yue LI
;
Nan TANG
Author Information
1. 重庆大学附属涪陵医院呼吸与危重症医学科,重庆 408000
- Keywords:
non-small cell lung cancer;
melanoma differentiation associated gene 5;
treatment;
inter-stitial lung disease
- From:
International Journal of Laboratory Medicine
2024;45(23):2894-2898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of melanoma differentiation associated gene 5(MDA5)in non-small cell lung cancer(NSCLC)and its value in predicting the development of interstitial lung disease during treatment.Methods A total of 49 cases of surgically resected NSCLC tissues and 99 cases of NSCLC tissues by lung needle biopsy or fiberoptic bronchoscopy from January 2020 to June 2023 in the hospital were collected,and 148 cases of normal tissues(more than 5 cm from the lesion tissue)were taken as controls.The expression of MDA5 was detected by immunohistochemistry,and the relationship between the expression of MDA5 and the clinicopathological characteristics of NSCLC patients was analyzed.A total of 95 NSCLC pa-tients who received comprehensive treatment were followed up,and the risk factors of interstitial lung disease were analyzed.Results The positive expression rate of MDA5 in 148 NSCLC tissues was 66.22％,but in nor-mal lung tissues,only type Ⅱ alveolar cells and macrophages showed weak non-specific staining.The positive expression rate of MDA5 in patients with adenocarcinoma was significantly higher than that in patients with squamous cell carcinoma(73.63％vs.54.39％.P＜0.05).The positive expression rate of MDA5 in smoking patients was significantly higher than that in non-smoking patients(73.12％vs.54.55％,P＜0.05).The in-cidence rate of interstitial lung disease in smoking patients was significantly higher than that in non-smoking patients(27.94％vs.7.41％,P＜0.05).The incidence rate of interstitial lung disease in patients with stageⅢ-Ⅳ was also significantly higher than that in patients with stage Ⅰ-Ⅱ(P＜0.05).Receiver operating characteristic curve analysis showed that the area under the curve of MDA5 in predicting interstitial lung dis-ease during treatment of NSCLC was 0.6,the sensitivity was 77.3％and the specificity was 57.5％.Conclu-sion MDA5 plays an important role in the development of NSCLC,and may play a certain role in predicting the possible occurrence of interstitial lung disease in lung cancer patients during treatment.Smoking and ad-vanced stage are high risk factors for the development of interstitial lung disease.
