Diagnostic value of video head impulse test combined with serum CGRP and Ficolin-3 in patients with vestibular neuritis
10.3969/j.issn.1673-4130.2024.23.014
- VernacularTitle:视频头脉冲试验联合血清CGRP、Ficolin-3对前庭神经炎患者的诊断价值分析
- Author:
Junjun GUO
1
;
Bin LI
;
Guijuan ZHOU
;
Jia GUO
Author Information
1. 唐山市人民医院神经内科,河北唐山 063000
- Keywords:
vestibular neuritis;
video head impulse test;
calcitonin gene related peptide;
Ficolin-3
- From:
International Journal of Laboratory Medicine
2024;45(23):2889-2893,2898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of video head impulse test(vHIT)combined with serum calcitonin gene related peptide(CGRP)and Ficolin-3 in patients with vestibular neuritis(VN).Methods A total of 92 VN patients treated in the hospital from March 2021 to September 2023 were assigned as the VN group,92 vestibular migraines(VM)patients treated in the hospital during the same period were assigned as the VM group,and another 92 healthy individuals who underwent physical examination in the hospital were assigned as the control group.The levels of CGRP and Ficolin-3 in serum were compared in three groups.Multivariate Logistic regression was applied to analyze the influencing factors of VN occurrence.Receiver operating charac-teristic curve was applied to analyze the diagnostic value of vHIT combined with serum CGRP and Ficolin-3 levels for VN.Results Compared with the control group,the serum CGRP levels in the VN group and the VM group were obviously increased(P＜0.05),while the Ficolin-3 levels were obviously reduced(P＜0.05).Compared with the VM group,the serum CGRP level and 3 pairs of vestibular ocular reflex(VOR)gain a-symmetry values in the VN group were obviously increased(P＜0.05),while the Ficolin-3 level was obvious-ly reduced(P＜0.05).Horizontal semicircular canal(HC)asymmetry value,superior semicircular canal(AC)asymmetry value,posterior semicircular canal(PC)asymmetry value,and CGRP were independent risk factors for VN occurrence(P＜0.05),while Ficolin-3 was an independent protective factor for VN occurrence(P＜0.05).The area under the curve(AUC)of combined detection of AC asymmetry value,HC asymmetry value and PC asymmetry was 0.872,which was better than that of AC asymmetry value and HC asymmetry value alone(Z three combination-AC asymmetry value=2.506,Z three combination-HC asymmetry value-2.329,P=0.012,0.020).The AUC of HC asymmetry value,AC asymmetry value,PC asymmetry value,serum CGRP and Ficolin-3 for diagnosing VN was 0.782,0.787,0.856,0.857,and 0.881,respectively.The AUC of the combined diagnosis of the five was 0.948,which was better than those of the individual diagnosis(Z five combination-HC asymmetry value=4.578,five combination-AC asymmetry value-4.908,Zfive combination-PC asymmetry value 3.085,Z five combination-CGRP=3.559,Z five combination-Ficolin-32.867,P＜0.05).Conclusion Serum CGRP level is increased and Ficolin-3 level is decreased in VN patients.CGRP is an independent risk factor for VN occurrence,and Ficolin-3 is an independent protective factor for VN occurrence.The combination of vHIT,CGRP,and Ficolin-3 has high diagnostic value for VN.
