Relationship between peripheral blood NLR and LDH level with seizures and brain damage in children with febrile convulsions
10.3969/j.issn.1673-4130.2024.23.012
- VernacularTitle:热性惊厥患儿外周血NLR、LDH水平与病情发作情况及脑损伤的关系研究
- Author:
Le ZHAO
1
;
Jie SUN
;
Xuan FENG
Author Information
1. 山西省儿童医院(山西省妇幼保健院)院前急救,山西太原 030000
- Keywords:
febrile convulsions;
neutrophil-lymphocyte ratio;
lactate dehydrogenase;
seizures;
brain damage
- From:
International Journal of Laboratory Medicine
2024;45(23):2878-2882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between peripheral blood neutrophil-to-lymphocyte ratio(NLR)and lactate dehydrogenase(LDH)level with seizures and brain damage in children with febrile convulsions(FC).Methods A total of 134 children with FC in the hospital from April 2021 to August 2023 were selected as observation group.Another 134 children with respiratory tract infections but without FC from the same period in the hospital were selected as the control group.FC children were further classified in-to mild group(frequency＜2 times and duration＜10 min,79 cases)and severe group(frequency≥2 times or duration≥10 min,55 cases)according to the severity of seizures.NLR and LDH level between two groups were compared,Pearson correlation analysis was used to analyze the correlation between NLR,LDH level in FC children and seizures.FC children were re-divided into brain damage group(38 cases)and non-brain dam-age group(96 cases)according to the presence or absence of brain damage.Univariate and multivariate Logis-tic analysis were used to investigate the factors influencing the brain damage in children.Results NLR and LDH level were notably elevated in the observation group compared with the control group(P＜0.05),and the NLR and LDH level were higher in the severe group compared with the mild group(P＜0.05).NLR and LDH level in children with FC were positively correlated with the duration and frequency of seizures(P＜0.05).Compared with the non-brain damage group,the proportion of children who had seizures ≥2 times and lasted ≥10 min and NLR and LDH level in the brain damage group were higher(P＜0.05).Multivariate Lo-gistic regression analysis denoted that the frequency of seizures,duration of seizures,NLR and LDH level were independent risk factors affecting brain damage in children with FC(P＜0.05).Conclusion NLR and LDH level in peripheral blood of children with FC is positively correlated with the duration and frequency of sei-zures.Moreover,the frequency of seizures,duration of seizures,NLR and LDH level are all risk factors for brain damage in children with FC.
